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Concerning merge from acetylcholinesterase: I consciously merged the articles in the reverse direction because acetylcholinesterase is fully dealt with on this page. Moreover, as the current page mentions there are two enzymes referred to as cholinesterase. It would thus be erroneous or misleading at least to redirect cholinesterase to the other article. Notice I left the stub status there. -- Phils 17:05, 18 Oct 2004 (UTC)
Removed here, if someone could find the documents in question without page forwarding links, it'd be awesome. Otherwise will do later hopefully.
- Study showing magnolia oil as an acetylcholinesterase inhibitor.
- Cholinesterase inhibitors might alleviate methamphetamine-induced delusions, hallucinations and cognitive impairment, while reducing craving and addiction
—The preceding unsigned comment was added by Tom Meakin ( talk • contribs) 09:54, 31 January 2007 (UTC).
Revision as of 06:38, 22 August 2005 by 211.30.120.226 stated that
Cholinesterase inhibitors were discovered by Professor Cardillo of Sydney University, Australia.
On August 23rd 2005, User:Jfdwolff removed that part and commented:
Strychnine has been around for much longer
Although I'm unable to confirm the first statement, I know for sure that the counterargument doesn't stand. Even though the manifestations of a strychnine poisoning resemble that of a cholinesterase inhibitor massive overdose in that both may produce myoclonic or tetanic convulsion, strychnine is not a cholinesterase inhibitor.
Strychnine works by blocking the release of glycine from inhibitory interneurons in the spinal cord. This increases reflex excitability and result in convulsion.
Ref: Rang HP, Dale MM, Ritter JM. Pharmacology ISBN 0-443-05974-8
If someone can ascertain that a Professor Cardillo did discover cholinesterase inhibitor, please add it to the text and state your source.
Benoitduhaime 05:24, 9 October 2005 (UTC)
The result of the proposal was not to merge per consensus.
I think the title should be "Cholinesterases," but should not be merged with AChE page, as stated above. —Preceding unsigned comment added by Lpezzeme ( talk • contribs) 05:40, 13 October 2008 (UTC)
I totally agree (with Lpezzee, Boghog, CopperKettle) that the title of the "Cholinesterase enzyme" wiki.Page should be "Cholinesterase isoenzymes", containing all of the common conformational, reactive etc. features of the iso-enzymes of this "family" while only the specific differences between AChE, BChE, PChE and whatever else will be discovered out there should be reserved to be represented on those respective pages. —Preceding unsigned comment added by Waldemahr ( talk • contribs) 21:04, 18 June 2009 (UTC)
Oppose. Agree that the "family" of cholinesterase enzymes should be on this page, with text wiki-links to the two (or more) specific types. Simply "Cholinesterase" is fine as a title, everyone knows it's an enzyme and that's also stated at the top of the article. We don't need an "s" on the end just because there is more than one type, just as we have an article called "Dog" but not "Dogs" even though there is more than one type. Facts707 ( talk) 06:14, 25 October 2009 (UTC)
Please do not assign a EC number, examplified in the article, to a class of the enzymes
O...F..F...I...C...I...A...L
definition of EC number...??? -- 222.64.223.233 ( talk) 07:15, 30 July 2009 (UTC)
The result of the proposal was move per request. It turns out that this was cut and pasted from the move target in January 2007 and a history merge is required, which will also be done.-- Fuhghettaboutit ( talk) 13:55, 7 November 2009 (UTC)
Cholinesterase enzyme → Cholinesterase — Second word "enzyme" not necessary, implied by "ase" suffix and also stated in lead sentence of article] -- Facts707 ( talk) 17:37, 30 October 2009 (UTC)
it seems as though the question of WHY organophosphates inhibit this enzyme is skimmed, skipped, or glossed over (probably intentionally so)... It seems as though no authors are willing to say something as clear cut as: "the organophosphate inhibitors structurally resemble the activated tetrahedral transition state of enzyme bound acetylcholine, and inclusion of a leaving group that is labile upon reaction of the phosphorous center with the the serine residue results in an irreversibly deactivated enzyme" I have brought this up because this specific example is often used in introductory upper division biochemistry courses to help teach students about host-guest macromolecular chemistry, common enzymatic mechanisms (carbonyl-->tetrahedral Tstate stabilized by His residues for example), etc... Yet I see no mention of this, even with a big "warning" or "disclaimer" that says: "this information is not general, and not all classes of inhibitors function in this way" 68.6.76.31 ( talk) 21:09, 9 February 2011 (UTC)
The discussion of cholinesterase in pop culture is pretty worthless. Who cares if the word was used in a song title or some random TV show? It's not noteworthy. — Preceding unsigned comment added by 108.100.181.40 ( talk) 16:48, 6 January 2017 (UTC)
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This article:
The main type for that purpose is acetylcholinesterase (also called choline esterase I or erythrocyte cholinesterase)
Acetylcholinesterase article:
Acetylcholinesterase (HGNC symbol ACHE), also known as AChE or acetylhydrolase, ...
Biologist, this is chemist. Chemist, this is biologist. From now on, please nod politely as you pass each other in the corridors. — MaxEnt 19:32, 17 March 2018 (UTC)
Extension.
Cholinesterase inhibitors may alleviate delusions, hallucinations, and cognitive impairment caused by methamphetamine while reducing cravings and dependence...” In 2007.
:Symptoms of drug-induced reduction in A.Ch.E. ???
:Known: nausea, vomiting, diarrhea (diarrhea). Further: drowsiness, sleep (unconsciousness), coma, death.
:At what level of A.H.E. , - nausea? Level : A.H.E. , - diarrhea? At what level - unconsciousness and coma? ElvisorNr2 ( talk) 11:15, 11 October 2023 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||
|
Concerning merge from acetylcholinesterase: I consciously merged the articles in the reverse direction because acetylcholinesterase is fully dealt with on this page. Moreover, as the current page mentions there are two enzymes referred to as cholinesterase. It would thus be erroneous or misleading at least to redirect cholinesterase to the other article. Notice I left the stub status there. -- Phils 17:05, 18 Oct 2004 (UTC)
Removed here, if someone could find the documents in question without page forwarding links, it'd be awesome. Otherwise will do later hopefully.
- Study showing magnolia oil as an acetylcholinesterase inhibitor.
- Cholinesterase inhibitors might alleviate methamphetamine-induced delusions, hallucinations and cognitive impairment, while reducing craving and addiction
—The preceding unsigned comment was added by Tom Meakin ( talk • contribs) 09:54, 31 January 2007 (UTC).
Revision as of 06:38, 22 August 2005 by 211.30.120.226 stated that
Cholinesterase inhibitors were discovered by Professor Cardillo of Sydney University, Australia.
On August 23rd 2005, User:Jfdwolff removed that part and commented:
Strychnine has been around for much longer
Although I'm unable to confirm the first statement, I know for sure that the counterargument doesn't stand. Even though the manifestations of a strychnine poisoning resemble that of a cholinesterase inhibitor massive overdose in that both may produce myoclonic or tetanic convulsion, strychnine is not a cholinesterase inhibitor.
Strychnine works by blocking the release of glycine from inhibitory interneurons in the spinal cord. This increases reflex excitability and result in convulsion.
Ref: Rang HP, Dale MM, Ritter JM. Pharmacology ISBN 0-443-05974-8
If someone can ascertain that a Professor Cardillo did discover cholinesterase inhibitor, please add it to the text and state your source.
Benoitduhaime 05:24, 9 October 2005 (UTC)
The result of the proposal was not to merge per consensus.
I think the title should be "Cholinesterases," but should not be merged with AChE page, as stated above. —Preceding unsigned comment added by Lpezzeme ( talk • contribs) 05:40, 13 October 2008 (UTC)
I totally agree (with Lpezzee, Boghog, CopperKettle) that the title of the "Cholinesterase enzyme" wiki.Page should be "Cholinesterase isoenzymes", containing all of the common conformational, reactive etc. features of the iso-enzymes of this "family" while only the specific differences between AChE, BChE, PChE and whatever else will be discovered out there should be reserved to be represented on those respective pages. —Preceding unsigned comment added by Waldemahr ( talk • contribs) 21:04, 18 June 2009 (UTC)
Oppose. Agree that the "family" of cholinesterase enzymes should be on this page, with text wiki-links to the two (or more) specific types. Simply "Cholinesterase" is fine as a title, everyone knows it's an enzyme and that's also stated at the top of the article. We don't need an "s" on the end just because there is more than one type, just as we have an article called "Dog" but not "Dogs" even though there is more than one type. Facts707 ( talk) 06:14, 25 October 2009 (UTC)
Please do not assign a EC number, examplified in the article, to a class of the enzymes
O...F..F...I...C...I...A...L
definition of EC number...??? -- 222.64.223.233 ( talk) 07:15, 30 July 2009 (UTC)
The result of the proposal was move per request. It turns out that this was cut and pasted from the move target in January 2007 and a history merge is required, which will also be done.-- Fuhghettaboutit ( talk) 13:55, 7 November 2009 (UTC)
Cholinesterase enzyme → Cholinesterase — Second word "enzyme" not necessary, implied by "ase" suffix and also stated in lead sentence of article] -- Facts707 ( talk) 17:37, 30 October 2009 (UTC)
it seems as though the question of WHY organophosphates inhibit this enzyme is skimmed, skipped, or glossed over (probably intentionally so)... It seems as though no authors are willing to say something as clear cut as: "the organophosphate inhibitors structurally resemble the activated tetrahedral transition state of enzyme bound acetylcholine, and inclusion of a leaving group that is labile upon reaction of the phosphorous center with the the serine residue results in an irreversibly deactivated enzyme" I have brought this up because this specific example is often used in introductory upper division biochemistry courses to help teach students about host-guest macromolecular chemistry, common enzymatic mechanisms (carbonyl-->tetrahedral Tstate stabilized by His residues for example), etc... Yet I see no mention of this, even with a big "warning" or "disclaimer" that says: "this information is not general, and not all classes of inhibitors function in this way" 68.6.76.31 ( talk) 21:09, 9 February 2011 (UTC)
The discussion of cholinesterase in pop culture is pretty worthless. Who cares if the word was used in a song title or some random TV show? It's not noteworthy. — Preceding unsigned comment added by 108.100.181.40 ( talk) 16:48, 6 January 2017 (UTC)
Hello fellow Wikipedians,
I have just modified one external link on Cholinesterase. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 16:12, 5 August 2017 (UTC)
This article:
The main type for that purpose is acetylcholinesterase (also called choline esterase I or erythrocyte cholinesterase)
Acetylcholinesterase article:
Acetylcholinesterase (HGNC symbol ACHE), also known as AChE or acetylhydrolase, ...
Biologist, this is chemist. Chemist, this is biologist. From now on, please nod politely as you pass each other in the corridors. — MaxEnt 19:32, 17 March 2018 (UTC)
Extension.
Cholinesterase inhibitors may alleviate delusions, hallucinations, and cognitive impairment caused by methamphetamine while reducing cravings and dependence...” In 2007.
:Symptoms of drug-induced reduction in A.Ch.E. ???
:Known: nausea, vomiting, diarrhea (diarrhea). Further: drowsiness, sleep (unconsciousness), coma, death.
:At what level of A.H.E. , - nausea? Level : A.H.E. , - diarrhea? At what level - unconsciousness and coma? ElvisorNr2 ( talk) 11:15, 11 October 2023 (UTC)