![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||
|
![]() | On 25 February 2022, it was proposed that this article be moved from CRISPR/Cas12a to Cas12a. The result of the discussion was moved. |
Hello friends, I will be editing this Wikipedia entry for next few month. — Preceding unsigned comment added by Oscarjuez ( talk • contribs) 07:48, 26 February 2016 (UTC)
Hopefully! "Since cells must protect themselves against a host of viruses (to remove viral DNA), it has been hypothesized that each such virus has a complementary endonuclease," indicates some serious misunderstanding or missing proof reading... Yak90 ( talk) 00:09, 18 April 2016 (UTC)
This article has the tone of someone who has a vendetta against cas9. — Preceding unsigned comment added by 205.133.149.254 ( talk) 21:06, 29 January 2017 (UTC)
I agree with above, some of it sounds like ad-copy. I don't have a particular horse in this race but I'm going to try to note any real/potential challenges with Cpf1 and advantages/disadvantages compared to various site-specific nucleases. Although the more I looked through the research the cooler Cpf1 seems. Krb19 ( talk) 22:18, 27 December 2018 (UTC)
Source number four has no link? Tanner Stenlund ( talk) 20:42, 28 May 2020 (UTC)
Isn't CRISPR-Cas12 / CRISPR-Cas12a the same as cpf1 ? So isn't a rename in order ? See https://innovativegenomics.org/resources/educational-materials/glossary/cpf1-cas12/ and http://science.sciencemag.org/content/early/2018/02/14/science.aar6245 KVDP ( talk) 08:17, 27 March 2018 (UTC)
I'm pretty sure Cas12a is now the preferred term. Google scholar says that in the past 2 years, 6500 with "cas12a" and 1400 papers with "cpf1", and more with "cas12". I propose changing the article name to "Cas12a (Cpf1)" (and as opposed to current format of "CRISPR/Cpf1" to match the format of " Cas9"). Here is the paper [1] which (I think) first proposed the name change, based on sequence/structure homology (Cas12a/Cpf1 is essentially a Cas9 variant with a significant subunit/domain deletion, hence the small size).
I also think the name should be updated to CRISPR/Cas12, but I'm not sure how to edit the page name. All the literature I've seen recently has used Cas12 exclusively (though some mention the old name). AlkalineCoffee ( talk) 01:51, 9 March 2021 (UTC)
I have now renamed/moved the page to CRISPR/Cas12a and replaced most of the appearances of Cpf1 --> Cas12a in the body. Thanks everyone for your input. Krb19 ( talk) 11:50, 19 July 2021 (UTC)
References
{{
cite journal}}
: Check date values in: |date=
(
help)CS1 maint: PMC format (
link)
Same endonuclease invlolved. Cpf1 article is strict subset of Cas12a article: former talks about bioengineering only, latter talks about that and more. Artoria 2e5 🌉 03:40, 10 September 2021 (UTC)
I am going to BOLD it seeing there is a recent discussion. -- Artoria 2e5 🌉 06:05, 10 September 2021 (UTC)
The result of the move request was: moved. ( closed by non-admin page mover) Vpab15 ( talk) 22:46, 6 March 2022 (UTC)
CRISPR/Cas12a → Cas12a – Avoid subpage of CRISPR, consistent with Cas1 and Cas9. Taylor 49 ( talk) 19:59, 25 February 2022 (UTC)
![]() | This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||
|
![]() | On 25 February 2022, it was proposed that this article be moved from CRISPR/Cas12a to Cas12a. The result of the discussion was moved. |
Hello friends, I will be editing this Wikipedia entry for next few month. — Preceding unsigned comment added by Oscarjuez ( talk • contribs) 07:48, 26 February 2016 (UTC)
Hopefully! "Since cells must protect themselves against a host of viruses (to remove viral DNA), it has been hypothesized that each such virus has a complementary endonuclease," indicates some serious misunderstanding or missing proof reading... Yak90 ( talk) 00:09, 18 April 2016 (UTC)
This article has the tone of someone who has a vendetta against cas9. — Preceding unsigned comment added by 205.133.149.254 ( talk) 21:06, 29 January 2017 (UTC)
I agree with above, some of it sounds like ad-copy. I don't have a particular horse in this race but I'm going to try to note any real/potential challenges with Cpf1 and advantages/disadvantages compared to various site-specific nucleases. Although the more I looked through the research the cooler Cpf1 seems. Krb19 ( talk) 22:18, 27 December 2018 (UTC)
Source number four has no link? Tanner Stenlund ( talk) 20:42, 28 May 2020 (UTC)
Isn't CRISPR-Cas12 / CRISPR-Cas12a the same as cpf1 ? So isn't a rename in order ? See https://innovativegenomics.org/resources/educational-materials/glossary/cpf1-cas12/ and http://science.sciencemag.org/content/early/2018/02/14/science.aar6245 KVDP ( talk) 08:17, 27 March 2018 (UTC)
I'm pretty sure Cas12a is now the preferred term. Google scholar says that in the past 2 years, 6500 with "cas12a" and 1400 papers with "cpf1", and more with "cas12". I propose changing the article name to "Cas12a (Cpf1)" (and as opposed to current format of "CRISPR/Cpf1" to match the format of " Cas9"). Here is the paper [1] which (I think) first proposed the name change, based on sequence/structure homology (Cas12a/Cpf1 is essentially a Cas9 variant with a significant subunit/domain deletion, hence the small size).
I also think the name should be updated to CRISPR/Cas12, but I'm not sure how to edit the page name. All the literature I've seen recently has used Cas12 exclusively (though some mention the old name). AlkalineCoffee ( talk) 01:51, 9 March 2021 (UTC)
I have now renamed/moved the page to CRISPR/Cas12a and replaced most of the appearances of Cpf1 --> Cas12a in the body. Thanks everyone for your input. Krb19 ( talk) 11:50, 19 July 2021 (UTC)
References
{{
cite journal}}
: Check date values in: |date=
(
help)CS1 maint: PMC format (
link)
Same endonuclease invlolved. Cpf1 article is strict subset of Cas12a article: former talks about bioengineering only, latter talks about that and more. Artoria 2e5 🌉 03:40, 10 September 2021 (UTC)
I am going to BOLD it seeing there is a recent discussion. -- Artoria 2e5 🌉 06:05, 10 September 2021 (UTC)
The result of the move request was: moved. ( closed by non-admin page mover) Vpab15 ( talk) 22:46, 6 March 2022 (UTC)
CRISPR/Cas12a → Cas12a – Avoid subpage of CRISPR, consistent with Cas1 and Cas9. Taylor 49 ( talk) 19:59, 25 February 2022 (UTC)