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This article is exclusively about structure prediction, not RNA structure in general. Interesting facts related to RNA structure, but not prediction specifically, include: Depending on the structure, a given RNA molecule will have regions of relatively high or low accessibility. For mRNA, highly accessible regions are more sensitive to RNA-interference ( RNAi). Highly structured RNA slows and causes ribosomal pausing during translation (See Farabaugh, P. J. Programmed translational frameshifting. Microbiol. Rev. 60) (See Wen, J. D. et al. Following translation by single ribosomes one codon at a time.)
However, we already have a List of RNA structure prediction software, and we also have a section in the RNA article called Structure [ [1]], which mention secondary structure.
So, I guess the question is, what do we want this article to be about? -- Adamuu ( talk) 17:06, 6 August 2009 (UTC)
This article was moved from RNA structure as a result of a proposal at WT:MCB. RNA structure now redirects to Nucleic acid structure instead.
A number of redirects have been changed to point here (most notably Primary structure, Secondary structure, Tertiary structure, and Quaternary structure). Editors may want to consider redirecting these wikilinks to point to the appropriate protein or nucleic acid whateverary structure article instead. Antony-22 ( talk) 18:47, 10 April 2010 (UTC)
PLEASE EXPAND ARTICLE: INCLUDE ACCUARATE DIAGRAMS — Preceding unsigned comment added by Ridem92 ( talk • contribs) 17:32, 13 October 2010
I have two main problems with this article. The first is that its treatment of primary through quaternary structures is inconsistent and unclear. For starters, are all four levels of structure relevant to the same class of entities? If not, then which apply to which and why? As it currently reads, primary seems to apply to "biological molecules," while secondary applies to [at least some] biopolymers, tertiary applies to macromolecules, and finally quaternary applies to "protein molecules." Likewise, as it currently reads, primary applies within biochemistry, secondary within biochemistry and structural biology, tertiary within biochemistry and molecular biology, and quaternary once again within biochemistry. I suspect that this is just inconsistency deserving of some cleaning up, but I would not perform that cleaning up before knowing that it was indeed appropriate to do.
Secondly, the lead ought to do a better job of sketching out the similarities and differences between the four levels of structure. I'll focus these comments on the accompanying image (Protein_structure.png). It would appear that the image was included in order to convey the relationships between the four levels, but as for myself, I've had to puzzle several minutes over it before arriving at this (hypothesized!) interpretation:
Look, just because I was able to work all of that out doesn't mean that it's a good idea to require readers to slog through it on their own. If the above interpretation is correct, then the figure suffers a few design flaws. It requires one to march upstream against the natural top-to-bottom, left-to-right habit. It has some misleading placements and spacing that tend to obscure which bits of the image belong conceptually in a single cluster. It could unify the presentation of each level of structure by placing each atop a subtly chosen matte to create cohesion. My hunch is that the image was not produced specifically for this article, but for some other not-quite-similar application, and was merely put into service here without any tuning. Understandable but unfortunate.
Even if we can't generate a more easily interpreted image, if somebody who actually knows this stuff would kindly confirm my understanding, then I'd be willing to rework the text to walk nonbiologist readers through the example.— PaulTanenbaum ( talk) 16:40, 23 February 2016 (UTC)
![]() |
![]() |
{{
protein structure}}
and {{
RNA structure}}
). Hopefully they are a bit clearer than the original
file:protein structure.png image. I'll update the captions on each page that the image appears on to explain the highlighted features.
T.Shafee(Evo&Evo)
talk 05:06, 8 November 2016 (UTC)Many thanks to both @ Antony-22: and @ Evolution and evolvability: these figures are much, much clearer now. And that additional clarity has allowed me to take a swipe at expanding the lead a bit to make it gentler for non-specialists. I'd appreciate any comments, corrections, etc. on what this non-specialist has done there.— PaulTanenbaum ( talk) 16:43, 11 November 2016 (UTC)
The comment(s) below were originally left at Talk:Biomolecular structure/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
Rated "top" as highschool/SAT biology content; consistent with protein structure. - tameeria 02:35, 29 April 2007 (UTC) |
Last edited at 01:48, 1 January 2012 (UTC). Substituted at 09:42, 29 April 2016 (UTC)
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in the image lengend "6TNA 6TNA" url is broken — Preceding unsigned comment added by 62.1.209.51 ( talk) 17:23, 1 November 2020 (UTC)
![]() | This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||
|
This article is exclusively about structure prediction, not RNA structure in general. Interesting facts related to RNA structure, but not prediction specifically, include: Depending on the structure, a given RNA molecule will have regions of relatively high or low accessibility. For mRNA, highly accessible regions are more sensitive to RNA-interference ( RNAi). Highly structured RNA slows and causes ribosomal pausing during translation (See Farabaugh, P. J. Programmed translational frameshifting. Microbiol. Rev. 60) (See Wen, J. D. et al. Following translation by single ribosomes one codon at a time.)
However, we already have a List of RNA structure prediction software, and we also have a section in the RNA article called Structure [ [1]], which mention secondary structure.
So, I guess the question is, what do we want this article to be about? -- Adamuu ( talk) 17:06, 6 August 2009 (UTC)
This article was moved from RNA structure as a result of a proposal at WT:MCB. RNA structure now redirects to Nucleic acid structure instead.
A number of redirects have been changed to point here (most notably Primary structure, Secondary structure, Tertiary structure, and Quaternary structure). Editors may want to consider redirecting these wikilinks to point to the appropriate protein or nucleic acid whateverary structure article instead. Antony-22 ( talk) 18:47, 10 April 2010 (UTC)
PLEASE EXPAND ARTICLE: INCLUDE ACCUARATE DIAGRAMS — Preceding unsigned comment added by Ridem92 ( talk • contribs) 17:32, 13 October 2010
I have two main problems with this article. The first is that its treatment of primary through quaternary structures is inconsistent and unclear. For starters, are all four levels of structure relevant to the same class of entities? If not, then which apply to which and why? As it currently reads, primary seems to apply to "biological molecules," while secondary applies to [at least some] biopolymers, tertiary applies to macromolecules, and finally quaternary applies to "protein molecules." Likewise, as it currently reads, primary applies within biochemistry, secondary within biochemistry and structural biology, tertiary within biochemistry and molecular biology, and quaternary once again within biochemistry. I suspect that this is just inconsistency deserving of some cleaning up, but I would not perform that cleaning up before knowing that it was indeed appropriate to do.
Secondly, the lead ought to do a better job of sketching out the similarities and differences between the four levels of structure. I'll focus these comments on the accompanying image (Protein_structure.png). It would appear that the image was included in order to convey the relationships between the four levels, but as for myself, I've had to puzzle several minutes over it before arriving at this (hypothesized!) interpretation:
Look, just because I was able to work all of that out doesn't mean that it's a good idea to require readers to slog through it on their own. If the above interpretation is correct, then the figure suffers a few design flaws. It requires one to march upstream against the natural top-to-bottom, left-to-right habit. It has some misleading placements and spacing that tend to obscure which bits of the image belong conceptually in a single cluster. It could unify the presentation of each level of structure by placing each atop a subtly chosen matte to create cohesion. My hunch is that the image was not produced specifically for this article, but for some other not-quite-similar application, and was merely put into service here without any tuning. Understandable but unfortunate.
Even if we can't generate a more easily interpreted image, if somebody who actually knows this stuff would kindly confirm my understanding, then I'd be willing to rework the text to walk nonbiologist readers through the example.— PaulTanenbaum ( talk) 16:40, 23 February 2016 (UTC)
![]() |
![]() |
{{
protein structure}}
and {{
RNA structure}}
). Hopefully they are a bit clearer than the original
file:protein structure.png image. I'll update the captions on each page that the image appears on to explain the highlighted features.
T.Shafee(Evo&Evo)
talk 05:06, 8 November 2016 (UTC)Many thanks to both @ Antony-22: and @ Evolution and evolvability: these figures are much, much clearer now. And that additional clarity has allowed me to take a swipe at expanding the lead a bit to make it gentler for non-specialists. I'd appreciate any comments, corrections, etc. on what this non-specialist has done there.— PaulTanenbaum ( talk) 16:43, 11 November 2016 (UTC)
The comment(s) below were originally left at Talk:Biomolecular structure/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.
Rated "top" as highschool/SAT biology content; consistent with protein structure. - tameeria 02:35, 29 April 2007 (UTC) |
Last edited at 01:48, 1 January 2012 (UTC). Substituted at 09:42, 29 April 2016 (UTC)
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I have just modified one external link on Biomolecular structure. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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Cheers.— InternetArchiveBot ( Report bug) 19:20, 20 July 2017 (UTC)
in the image lengend "6TNA 6TNA" url is broken — Preceding unsigned comment added by 62.1.209.51 ( talk) 17:23, 1 November 2020 (UTC)