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This article doesn't say what the standard range of doses is, nor does it give the typical amount for an overdose. — 86.1.163.237 ( talk) 09:46, 21 September 2008 (UTC)
The section reads like an advertisement for Ameisen's books. If Baclofen is indeed useful for addiction treatment, this should be supported with relevant citations, and without continual reference to what is clearly a commercial venture. —Preceding unsigned comment added by 173.55.161.108 ( talk) 07:29, 18 June 2010 (UTC)
There have been indeed several formal tests to find out baclofen efficacy to treat addiction. I found two recent scientific papers stating precisely that:
-- RinzeWind ( talk) 18:58, 6 December 2008 (UTC)
(outdent) The study for alcoholics was only 30 days long; baclofen was administered 12 - 24 hours after the last drink to alcohol dependent individuals or placebo. Baclofen in my view was probably just suppressing alcohol withdrawal symptoms. Baclofen's suppression of temporary withdrawal symptoms may be being misinterpreted as being a successful treatment of alcoholism. We need to be careful about adding primary sources, especially weak primary sources and giving undue weight. We should try to add secondary sources, eg review papers and meta-analysis papers, per WP:MEDRS.-- Literaturegeek | T@1k? 00:12, 15 July 2010 (UTC)
What about something like: http://www.ncbi.nlm.nih.gov/pubmed/21414953?dopt=Abstract - a secondary analysis of some randomized, double-blind, placebo-controlled trial. February 2011? — Preceding unsigned comment added by 173.164.183.150 ( talk) 23:33, 26 May 2011 (UTC)
A prescribing guide has now been published in English after clinical experience over several years by doctors which has also resulted in the French alcohol agency recommending use of baclofen for alcoholism and a proposed RTU (Recommendation for Temporary Use) by the French government pending the completion of trials presently underway in France: http://www.sciencedomain.org/abstract.php?iid=315&id=12&aid=2459#.Ur--v_QW3RI
Should this be included because the US NIH have also begun a study: http://clinicalstudies.info.nih.gov/cgi/detail.cgi?A_2013-AA-0040.html
The topic of baclofen for alcoholism is also before the NICE in the UK for consideration of the issuing of guidelines based on best evidence. Restricting the article to only published double blind studies does not capture the state of play in baclofen research, nor the controversy which is evidenced by the conflicting comments on this Talk board. It is not so important to focus on trials in the case of baclofen because it is used for many conditions off-licence, such as nervous ticks and hiccups and was originally intended for epilepsy treatment. Restricting comment to licensed uses or trials ignores legitimate off-licence use which is indicated by medical professional regulatory codes of conduct. Burdenedwithtruth ( talk) 07:44, 29 December 2013 (UTC)
Baclofen is now used extensively for alcoholism in France and was approved there in 2013, being granted an RTU licence for three years pending further studies. Those studies were completed in May 2014 and the results are being prepared for presentation to the French Government so that the drug will be licensed for treatment of alcoholism nationwide. 195.175.63.174 ( talk) 05:02, 25 August 2014 (UTC)
Alcohol can be used to self-medicate against muscle spasm. Clearly not a good idea. If the user was honest about his/her use of alcohol, and baclofen were substituted for alcohol, obviously baclofen would trump the alcohol. The writer Christy Brown probably used alcohol in this way Wythy ( talk) 14:48, 12 November 2016 (UTC)
In the introduction, it says baclofen is an agonist for GABAB receptors, yet the "Mechanisms of Action" says it's an allosteric modulator. However, the mechanisms of action bit isn't referenced - the only thing that is referenced is the GHB bits. I looked up my Rang and Dale Pharmacology text and it says baclofen is a selective GABAB receptor - anyone got other sources to back this up? 123.211.190.87 ( talk) 03:33, 13 June 2011 (UTC)
It is an agonist. www.sciencedomain.org/download.php?f=Gache452013BJMMR7069... 77.92.17.160 ( talk) 04:11, 5 October 2014 (UTC)
Many sections have an Unreferenced section tag. However, all articles about pharmacology contain references to the nih pubchem db and others. Should we bother with littering such articles with unreferenced tags, when most references are practically implied? I agree it's a boring job to add the deep links, and as an example I added references to Pubchem entries for each mode of administration for this particular drug. (I had to lookup an entry for the oral mode, just reused the one in the box for intrathecal mode). Maybe we just need some macros for this type of thing. Henk Langeveld ( talk) 23:46, 12 March 2012 (UTC)
This article needs a significant amount of work.
The reference of: Autism In 2012, baclofen was suggested for treatment of autism.[11]
^ "Half Of Children With Autism Wander, Study Says". http://huffingtonpost.com.+October 7, 2012.
seems not to say anything about Baclofen or a connection between Baclofen and Autism!?
86.33.158.14 ( talk) 14:46, 4 January 2013 (UTC)
Listen to your gut http://ajcc.aacnjournals.org/content/15/6/611.full http://www.ncbi.nlm.nih.gov/pubmed/16454779 http://www.baclofenpump.com/living/during-treatment/underdose-overdose/index.htm http://emj.bmj.com/content/22/9/673.full http://www.mywayout.org/community/f20/baclofen-great-drug-but-also-extremely-deadly-60370.html http://www.drugs.com/baclofen.html http://multiple-sclerosis.emedtv.com/baclofen/baclofen-overdose.html This Sheise is bananas... — Preceding unsigned comment added by 173.217.250.87 ( talk) 18:37, 19 June 2014 (UTC)
The above post on an internet forum is of no help. This forum is notorious for people posting fake stories of problems with baclofen. There are no reported cases of deaths from oral administration of baclofen even in large overdoses. I don't know why this section is even here. There are plenty of peer reviewed papers on baclofen which are not hysterical. 77.92.17.160 ( talk) 05:04, 5 October 2014 (UTC)
"There are very few cases of abuse of baclofen for reasons other than attempted suicide.[6]". If there are only a very few cases of attempted suicide with Baclofen then this sentence needs to be reworded.
"Baclofen produces its effects by activating the GABAB receptor, similar to the drug phenibut which also activates this receptor and shares some of its effects. Baclofen is postulated to block mono-and-polysynaptic reflexes by acting as an inhibitory neurotransmitter, blocking the release of excitatory transmitters. However, baclofen does not have significant affinity for the GHB receptor, and has no known abuse potential.[12] "
First, what does in the first part of the section imply baclofen having an affinity for GHB receptor, that we need to say it does not? That sentence seems irrelevant, since GHB (which does bind to GHB receptor) is not even mentioned in the preceding sentences. Second, how is it that baclofen "has no known abuse potential" if the it causes a very serious benzodiazepine-like withdrawal syndrome and is a well-known drug of abuse in Russia (as stated in the article itself)? -- 78.84.59.209 ( talk) 20:29, 26 March 2016 (UTC)
"it does not produce euphoria or other pleasant effects" and "Baclofen is a very well-known drug of abuse in Russia." is pretty meaningless. Baclofen DOES produce euphoria and "high" in dosage of about 125mg, a halfway between alcohol and "Extasy" (MDMA) experience. Just buy it and try it if you need a proof. — Preceding unsigned comment added by 94.102.122.86 ( talk) 18:45, 7 March 2017 (UTC)
{{
cite journal}}
: CS1 maint: unflagged free DOI (
link)Also there is one very interesting paper about phenibut (dechlorinated baclofen analog) dependence alleviated by baclofen:
62.192.231.70 ( talk) 15:28, 13 May 2017 (UTC)
As someone who uses Baclofen at high doses to treat alcohol cravings I can definitely attest that it produces euphoria, highly increased libido with anorgasmia, mania, confusion, forgetfulness, a drunk-like feeling that does NOT involve loss of coordination or slurred speech, increased confidence and disinhibition amongst other things. Dosage must be very carefully controlled to avoid extremely unpleasant side-effects due to overdose. I'm amazed actually at how liberally it is prescribed. If doctors really knew what they were handing out they'd be horrified. It ought to be a strictly controlled drug like Valium, but I'm glad it's not, yet anyway, because it did save my life, literally. — Preceding unsigned comment added by Duprie37 ( talk • contribs) 08:22, 31 May 2019 (UTC)
I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Baclofen's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "chou":
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT ⚡ 07:46, 7 January 2018 (UTC)
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about Baclofen.
|
This article doesn't say what the standard range of doses is, nor does it give the typical amount for an overdose. — 86.1.163.237 ( talk) 09:46, 21 September 2008 (UTC)
The section reads like an advertisement for Ameisen's books. If Baclofen is indeed useful for addiction treatment, this should be supported with relevant citations, and without continual reference to what is clearly a commercial venture. —Preceding unsigned comment added by 173.55.161.108 ( talk) 07:29, 18 June 2010 (UTC)
There have been indeed several formal tests to find out baclofen efficacy to treat addiction. I found two recent scientific papers stating precisely that:
-- RinzeWind ( talk) 18:58, 6 December 2008 (UTC)
(outdent) The study for alcoholics was only 30 days long; baclofen was administered 12 - 24 hours after the last drink to alcohol dependent individuals or placebo. Baclofen in my view was probably just suppressing alcohol withdrawal symptoms. Baclofen's suppression of temporary withdrawal symptoms may be being misinterpreted as being a successful treatment of alcoholism. We need to be careful about adding primary sources, especially weak primary sources and giving undue weight. We should try to add secondary sources, eg review papers and meta-analysis papers, per WP:MEDRS.-- Literaturegeek | T@1k? 00:12, 15 July 2010 (UTC)
What about something like: http://www.ncbi.nlm.nih.gov/pubmed/21414953?dopt=Abstract - a secondary analysis of some randomized, double-blind, placebo-controlled trial. February 2011? — Preceding unsigned comment added by 173.164.183.150 ( talk) 23:33, 26 May 2011 (UTC)
A prescribing guide has now been published in English after clinical experience over several years by doctors which has also resulted in the French alcohol agency recommending use of baclofen for alcoholism and a proposed RTU (Recommendation for Temporary Use) by the French government pending the completion of trials presently underway in France: http://www.sciencedomain.org/abstract.php?iid=315&id=12&aid=2459#.Ur--v_QW3RI
Should this be included because the US NIH have also begun a study: http://clinicalstudies.info.nih.gov/cgi/detail.cgi?A_2013-AA-0040.html
The topic of baclofen for alcoholism is also before the NICE in the UK for consideration of the issuing of guidelines based on best evidence. Restricting the article to only published double blind studies does not capture the state of play in baclofen research, nor the controversy which is evidenced by the conflicting comments on this Talk board. It is not so important to focus on trials in the case of baclofen because it is used for many conditions off-licence, such as nervous ticks and hiccups and was originally intended for epilepsy treatment. Restricting comment to licensed uses or trials ignores legitimate off-licence use which is indicated by medical professional regulatory codes of conduct. Burdenedwithtruth ( talk) 07:44, 29 December 2013 (UTC)
Baclofen is now used extensively for alcoholism in France and was approved there in 2013, being granted an RTU licence for three years pending further studies. Those studies were completed in May 2014 and the results are being prepared for presentation to the French Government so that the drug will be licensed for treatment of alcoholism nationwide. 195.175.63.174 ( talk) 05:02, 25 August 2014 (UTC)
Alcohol can be used to self-medicate against muscle spasm. Clearly not a good idea. If the user was honest about his/her use of alcohol, and baclofen were substituted for alcohol, obviously baclofen would trump the alcohol. The writer Christy Brown probably used alcohol in this way Wythy ( talk) 14:48, 12 November 2016 (UTC)
In the introduction, it says baclofen is an agonist for GABAB receptors, yet the "Mechanisms of Action" says it's an allosteric modulator. However, the mechanisms of action bit isn't referenced - the only thing that is referenced is the GHB bits. I looked up my Rang and Dale Pharmacology text and it says baclofen is a selective GABAB receptor - anyone got other sources to back this up? 123.211.190.87 ( talk) 03:33, 13 June 2011 (UTC)
It is an agonist. www.sciencedomain.org/download.php?f=Gache452013BJMMR7069... 77.92.17.160 ( talk) 04:11, 5 October 2014 (UTC)
Many sections have an Unreferenced section tag. However, all articles about pharmacology contain references to the nih pubchem db and others. Should we bother with littering such articles with unreferenced tags, when most references are practically implied? I agree it's a boring job to add the deep links, and as an example I added references to Pubchem entries for each mode of administration for this particular drug. (I had to lookup an entry for the oral mode, just reused the one in the box for intrathecal mode). Maybe we just need some macros for this type of thing. Henk Langeveld ( talk) 23:46, 12 March 2012 (UTC)
This article needs a significant amount of work.
The reference of: Autism In 2012, baclofen was suggested for treatment of autism.[11]
^ "Half Of Children With Autism Wander, Study Says". http://huffingtonpost.com.+October 7, 2012.
seems not to say anything about Baclofen or a connection between Baclofen and Autism!?
86.33.158.14 ( talk) 14:46, 4 January 2013 (UTC)
Listen to your gut http://ajcc.aacnjournals.org/content/15/6/611.full http://www.ncbi.nlm.nih.gov/pubmed/16454779 http://www.baclofenpump.com/living/during-treatment/underdose-overdose/index.htm http://emj.bmj.com/content/22/9/673.full http://www.mywayout.org/community/f20/baclofen-great-drug-but-also-extremely-deadly-60370.html http://www.drugs.com/baclofen.html http://multiple-sclerosis.emedtv.com/baclofen/baclofen-overdose.html This Sheise is bananas... — Preceding unsigned comment added by 173.217.250.87 ( talk) 18:37, 19 June 2014 (UTC)
The above post on an internet forum is of no help. This forum is notorious for people posting fake stories of problems with baclofen. There are no reported cases of deaths from oral administration of baclofen even in large overdoses. I don't know why this section is even here. There are plenty of peer reviewed papers on baclofen which are not hysterical. 77.92.17.160 ( talk) 05:04, 5 October 2014 (UTC)
"There are very few cases of abuse of baclofen for reasons other than attempted suicide.[6]". If there are only a very few cases of attempted suicide with Baclofen then this sentence needs to be reworded.
"Baclofen produces its effects by activating the GABAB receptor, similar to the drug phenibut which also activates this receptor and shares some of its effects. Baclofen is postulated to block mono-and-polysynaptic reflexes by acting as an inhibitory neurotransmitter, blocking the release of excitatory transmitters. However, baclofen does not have significant affinity for the GHB receptor, and has no known abuse potential.[12] "
First, what does in the first part of the section imply baclofen having an affinity for GHB receptor, that we need to say it does not? That sentence seems irrelevant, since GHB (which does bind to GHB receptor) is not even mentioned in the preceding sentences. Second, how is it that baclofen "has no known abuse potential" if the it causes a very serious benzodiazepine-like withdrawal syndrome and is a well-known drug of abuse in Russia (as stated in the article itself)? -- 78.84.59.209 ( talk) 20:29, 26 March 2016 (UTC)
"it does not produce euphoria or other pleasant effects" and "Baclofen is a very well-known drug of abuse in Russia." is pretty meaningless. Baclofen DOES produce euphoria and "high" in dosage of about 125mg, a halfway between alcohol and "Extasy" (MDMA) experience. Just buy it and try it if you need a proof. — Preceding unsigned comment added by 94.102.122.86 ( talk) 18:45, 7 March 2017 (UTC)
{{
cite journal}}
: CS1 maint: unflagged free DOI (
link)Also there is one very interesting paper about phenibut (dechlorinated baclofen analog) dependence alleviated by baclofen:
62.192.231.70 ( talk) 15:28, 13 May 2017 (UTC)
As someone who uses Baclofen at high doses to treat alcohol cravings I can definitely attest that it produces euphoria, highly increased libido with anorgasmia, mania, confusion, forgetfulness, a drunk-like feeling that does NOT involve loss of coordination or slurred speech, increased confidence and disinhibition amongst other things. Dosage must be very carefully controlled to avoid extremely unpleasant side-effects due to overdose. I'm amazed actually at how liberally it is prescribed. If doctors really knew what they were handing out they'd be horrified. It ought to be a strictly controlled drug like Valium, but I'm glad it's not, yet anyway, because it did save my life, literally. — Preceding unsigned comment added by Duprie37 ( talk • contribs) 08:22, 31 May 2019 (UTC)
I check pages listed in Category:Pages with incorrect ref formatting to try to fix reference errors. One of the things I do is look for content for orphaned references in wikilinked articles. I have found content for some of Baclofen's orphans, the problem is that I found more than one version. I can't determine which (if any) is correct for this article, so I am asking for a sentient editor to look it over and copy the correct ref content into this article.
Reference named "chou":
I apologize if any of the above are effectively identical; I am just a simple computer program, so I can't determine whether minor differences are significant or not. AnomieBOT ⚡ 07:46, 7 January 2018 (UTC)