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In my very humble opinion, and not having contributed substantively very much, this article has become sort of bloggy, pushing the recent news on the possibility of As replacing P in some microorganisms. That news is very topical, but an encyclopedia article should emphasize more conventional material, i.e. real As-containing biomolecules (there are several As-natural products) and authenticated roles of As in biology (e.g. Arsenic#Biomethylation of arsenic). The problems that stick out to me are the following:
Sorry for my grumpy comments... I will try to add some content, which is more productive.-- Smokefoot ( talk) 01:19, 4 January 2011 (UTC)
The section on "prebiotic arsenic" has no business in an article on biochemistry, by definition. Otherwise the article invites essays on diverse arsenic minerals, Stellar nucleosynthesis etc. Probably this section might be better sited in arsenic. Anyway, as I have said above, the section comes close as original research (it is a fascinating subject).-- Smokefoot ( talk) 18:17, 9 January 2011 (UTC)
A couple of years ago the article expanded with a lot of speculation that As could replace phosphate in all sorts of biological functions. The key paper has basically been killed off. So now is a good time to start unwinding this misleading content. My recommendation would be to contract the relevant articles rather than present a lot of hand-wringing. The two new articles in Science are mentioned in http://www.bbc.co.uk/news/science-environment-18770964. I hope that the contributing editors will prove as enthusiastic about completing their work. -- Smokefoot ( talk) 13:05, 10 July 2012 (UTC)
Recent work has questioned whether methylation of arsenic detoxifies it, or whether it actually makes it more toxic. For example, Bergquist et. al. found that monomethylated arsenicIII was a more effective inhibitor of pyruvate dehydrogenase than inorganic AsIII, although dimethylated AsIII was less effective than either of them. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685281/ The page on arsenic toxicity http://en.wikipedia.org/wiki/Arsenic_toxicity mentions some of these new findings. 163.11.224.111 ( talk) 17:24, 30 November 2013 (UTC)
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A substantial portion of this article is reproduced (thinly disguised)in Sattar et al., 'Metabolism and toxicity of arsenicals in mammals,' Environmental Toxicology and Pharmacology, Vol. 48, 2016. KayemH ( talk) 18:08, 2 December 2016 (UTC)
This is the
talk page for discussing improvements to the
Arsenic biochemistry article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find sources: Google ( books · news · scholar · free images · WP refs) · FENS · JSTOR · TWL |
Archives: 1 |
This article is rated B-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||
|
This article was the subject of an educational assignment in April 2015. |
In my very humble opinion, and not having contributed substantively very much, this article has become sort of bloggy, pushing the recent news on the possibility of As replacing P in some microorganisms. That news is very topical, but an encyclopedia article should emphasize more conventional material, i.e. real As-containing biomolecules (there are several As-natural products) and authenticated roles of As in biology (e.g. Arsenic#Biomethylation of arsenic). The problems that stick out to me are the following:
Sorry for my grumpy comments... I will try to add some content, which is more productive.-- Smokefoot ( talk) 01:19, 4 January 2011 (UTC)
The section on "prebiotic arsenic" has no business in an article on biochemistry, by definition. Otherwise the article invites essays on diverse arsenic minerals, Stellar nucleosynthesis etc. Probably this section might be better sited in arsenic. Anyway, as I have said above, the section comes close as original research (it is a fascinating subject).-- Smokefoot ( talk) 18:17, 9 January 2011 (UTC)
A couple of years ago the article expanded with a lot of speculation that As could replace phosphate in all sorts of biological functions. The key paper has basically been killed off. So now is a good time to start unwinding this misleading content. My recommendation would be to contract the relevant articles rather than present a lot of hand-wringing. The two new articles in Science are mentioned in http://www.bbc.co.uk/news/science-environment-18770964. I hope that the contributing editors will prove as enthusiastic about completing their work. -- Smokefoot ( talk) 13:05, 10 July 2012 (UTC)
Recent work has questioned whether methylation of arsenic detoxifies it, or whether it actually makes it more toxic. For example, Bergquist et. al. found that monomethylated arsenicIII was a more effective inhibitor of pyruvate dehydrogenase than inorganic AsIII, although dimethylated AsIII was less effective than either of them. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685281/ The page on arsenic toxicity http://en.wikipedia.org/wiki/Arsenic_toxicity mentions some of these new findings. 163.11.224.111 ( talk) 17:24, 30 November 2013 (UTC)
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(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 16:10, 18 October 2016 (UTC)
A substantial portion of this article is reproduced (thinly disguised)in Sattar et al., 'Metabolism and toxicity of arsenicals in mammals,' Environmental Toxicology and Pharmacology, Vol. 48, 2016. KayemH ( talk) 18:08, 2 December 2016 (UTC)