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This sentence is in your Anatomy section: “The vagal triangle overlies the dorsal vagal nucleus and it situated on the caudal end…” and I think that instead of “it” you meant “is.” Otherwise, this section is very informational and cohesive.
You end your article by saying that “research on this circumventricular organ has continued to thrive,” but you do not talk about any ongoing studies. Are there any? What is the aim of continuing to study this? It would be good to have at least one article to back that statement to talk about research today and possible directions it may take. Development of the area postrema: An immunohistochemical study in the macaque, Brain Research, Volume 1280, 14 July 2009, Pages 23-32. This is a paper that talks about a monkey model used to study the area postrema. Maybe talking about their research would be a valuable addition that could back your statement that this research is continuing to thrive. Also in this article, there is a large amount of mechanistic information. Most of it is thick and may bog down your article if you take too much from it, but maybe an example would be useful? Aaron.fishman ( talk) —Preceding undated comment added 23:26, 22 November 2009 (UTC).
I found an article that could definitely help elaborate and expand on the point you make in the 2nd paragraph of the Pathology section. You state, "Stimulation of the dopamine receptors in the area postrema activates the vomiting centers of the brain; this is why nausea is one of the most common side effects of antiparkinsonian drugs." The article by Yoshikawa and Yoshida, titled Effect of 6-Hydroxydopamine Treatment in the Area Postrema on Morphine-Induced Emesis in Ferrets, describes how the treatment of ferrets with 6-hydroxydopamine into the area postrema reduced the nausea associated with dopamine-induced vomiting by lowering levels of dopamine and homovanilic acid. Thus, this article could be used as a point to explain how certain drugs are able to reduce nausea and vomiting, while also further defining the effect of dopamine on nausea and vomiting. The article is found at this url: http://www.jstage.jst.go.jp/article/jjp/89/4/89_422/_article/-char/en. Hope this helps. Giantsjs2000 ( talk) 00:16, 24 November 2009 (UTC)
The formatting of this section could be improved to make it more like the others. Also, I believe Lithium Chloride falls under the category of spurious captilization. Hassan.zayn ( talk) 09:39, 25 November 2009 (UTC)
Bellamen( talk) 02:19, 30 November 2009 (UTC)
I think that the pathology section of this article could also be expanded upon to include more about the conditioned taste aversion. When researching this I found many articles about this. I think that this section is very interesting and is a more, every day relevant concept regarding the area postrema. The best article I found was Toxin-induced conditioned changes in taste reactivity and the role of the chemosensitive area postrema by OssenKopp and Eckel. Also, I found that lesions to the area postrema could either enhance the avoidance of the toxin or eliminate the avoidance of the toxin. I found this very interesting and wonder if there is any connection to a specific type of toxin that either gets enhanced or eliminated and why some work one way and some work in the other when there are area postrema lesions. Overall really good informative article. ( Neurodana ( talk) 03:57, 30 November 2009 (UTC))
The information about concerning the disease is very detailed and very informative. The layout of the information can be more wikipedia friendly. There could be a specific section, which specifically discusses the malformations/lesions of the area postrema. I noticed in the article that lesions of the area postrema are sometimes referred to as “ ‘central vagotomy’ because they eliminate the brain’s ability to monitor the physiological status through its vagus nerve.” I would suggest making this a specific subsection so that wikipedia readers can easily find it when they come on your page. Explain how people develop this malformations or lesions to the area postrema. Is it through cranial damage or is it hereditary.
There also could be another section discussing similarities between area postrema and other disorders which were mentioned in the article. I know that there similarities/correlation between that of Parkinson disease and area postrema in terms of affecting movement. I noticed that you discuss the how both disorders are affected dopamine receptors. In “Principles of Pharmacology: the Pathophysiologic basis of drug therapy, I noted the D2 receptors are affected in the area postrema and you can see if there are similarities in any other of the disorders which explains the similarities. A treatment sections discussing how patients treat or deal with these lesions whether it is through surgery or drugs which affect neurotransmitters such as the dopamine receptors.
I also noted that was a history section and current research section and I thought that it would be good to separate them. Perhaps put the history section in the beginning and the current research section at the end. I also thought that that it would be helpful to have a social section, which describes what patients with these disease can contact for emotional support.
( jesspf ( talk) 11:43, 29 November 2009 (UTC))
Wikiation ( talk) 17:27, 3 September 2016 (UTC)
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This sentence is in your Anatomy section: “The vagal triangle overlies the dorsal vagal nucleus and it situated on the caudal end…” and I think that instead of “it” you meant “is.” Otherwise, this section is very informational and cohesive.
You end your article by saying that “research on this circumventricular organ has continued to thrive,” but you do not talk about any ongoing studies. Are there any? What is the aim of continuing to study this? It would be good to have at least one article to back that statement to talk about research today and possible directions it may take. Development of the area postrema: An immunohistochemical study in the macaque, Brain Research, Volume 1280, 14 July 2009, Pages 23-32. This is a paper that talks about a monkey model used to study the area postrema. Maybe talking about their research would be a valuable addition that could back your statement that this research is continuing to thrive. Also in this article, there is a large amount of mechanistic information. Most of it is thick and may bog down your article if you take too much from it, but maybe an example would be useful? Aaron.fishman ( talk) —Preceding undated comment added 23:26, 22 November 2009 (UTC).
I found an article that could definitely help elaborate and expand on the point you make in the 2nd paragraph of the Pathology section. You state, "Stimulation of the dopamine receptors in the area postrema activates the vomiting centers of the brain; this is why nausea is one of the most common side effects of antiparkinsonian drugs." The article by Yoshikawa and Yoshida, titled Effect of 6-Hydroxydopamine Treatment in the Area Postrema on Morphine-Induced Emesis in Ferrets, describes how the treatment of ferrets with 6-hydroxydopamine into the area postrema reduced the nausea associated with dopamine-induced vomiting by lowering levels of dopamine and homovanilic acid. Thus, this article could be used as a point to explain how certain drugs are able to reduce nausea and vomiting, while also further defining the effect of dopamine on nausea and vomiting. The article is found at this url: http://www.jstage.jst.go.jp/article/jjp/89/4/89_422/_article/-char/en. Hope this helps. Giantsjs2000 ( talk) 00:16, 24 November 2009 (UTC)
The formatting of this section could be improved to make it more like the others. Also, I believe Lithium Chloride falls under the category of spurious captilization. Hassan.zayn ( talk) 09:39, 25 November 2009 (UTC)
Bellamen( talk) 02:19, 30 November 2009 (UTC)
I think that the pathology section of this article could also be expanded upon to include more about the conditioned taste aversion. When researching this I found many articles about this. I think that this section is very interesting and is a more, every day relevant concept regarding the area postrema. The best article I found was Toxin-induced conditioned changes in taste reactivity and the role of the chemosensitive area postrema by OssenKopp and Eckel. Also, I found that lesions to the area postrema could either enhance the avoidance of the toxin or eliminate the avoidance of the toxin. I found this very interesting and wonder if there is any connection to a specific type of toxin that either gets enhanced or eliminated and why some work one way and some work in the other when there are area postrema lesions. Overall really good informative article. ( Neurodana ( talk) 03:57, 30 November 2009 (UTC))
The information about concerning the disease is very detailed and very informative. The layout of the information can be more wikipedia friendly. There could be a specific section, which specifically discusses the malformations/lesions of the area postrema. I noticed in the article that lesions of the area postrema are sometimes referred to as “ ‘central vagotomy’ because they eliminate the brain’s ability to monitor the physiological status through its vagus nerve.” I would suggest making this a specific subsection so that wikipedia readers can easily find it when they come on your page. Explain how people develop this malformations or lesions to the area postrema. Is it through cranial damage or is it hereditary.
There also could be another section discussing similarities between area postrema and other disorders which were mentioned in the article. I know that there similarities/correlation between that of Parkinson disease and area postrema in terms of affecting movement. I noticed that you discuss the how both disorders are affected dopamine receptors. In “Principles of Pharmacology: the Pathophysiologic basis of drug therapy, I noted the D2 receptors are affected in the area postrema and you can see if there are similarities in any other of the disorders which explains the similarities. A treatment sections discussing how patients treat or deal with these lesions whether it is through surgery or drugs which affect neurotransmitters such as the dopamine receptors.
I also noted that was a history section and current research section and I thought that it would be good to separate them. Perhaps put the history section in the beginning and the current research section at the end. I also thought that that it would be helpful to have a social section, which describes what patients with these disease can contact for emotional support.
( jesspf ( talk) 11:43, 29 November 2009 (UTC))
Wikiation ( talk) 17:27, 3 September 2016 (UTC)
Hello fellow Wikipedians,
I have just modified 2 external links on Area postrema. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
{{
dead link}}
tag to
https://www.neuinfo.org/mynif/search.php?q=Area%20Postrema&t=data&s=cover&b=0&r=20When you have finished reviewing my changes, please set the checked parameter below to true or failed to let others know (documentation at {{
Sourcecheck}}
).
An editor has determined that the edit contains an error somewhere. Please follow the instructions below and mark the
|checked=
to true
Cheers.— InternetArchiveBot ( Report bug) 13:02, 17 October 2016 (UTC)