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I'm concerned about the figure, which seems to suggest that sensory neurons from the skin typically terminate in the spinal column. As far as I am aware, the vast majority project to the brain, with the first connection occurring in the cuneate nucleus. 82.230.75.45 21:36, 11 July 2016 (UTC)
Question 1. Is there a single long fiber that goes from the skin to the brain?
Answer: No. Sensory neurons make synaptic connections to spinal cord interneurons which, in turn, form myelinated fiber bundles that project to the brain.
Question 2. What is the anatomy of a sensory neuron?
Answer: Note this is a simplification, but in general... Sensory neurons have cell bodies in the dorsal root ganglion (see Figure-1). These neurons are considered pseudounipolar (see Figure-2). You can think of this unique subtype as consisting of just one long axon, that happens to have a cell body transit station smack-in-the-middle. That is, the axon starts at the skin, and is connected to some specialized sensor (now that might sound like a dendrite, so if it helps, just think of the sensor filling the role of the dendrite, so then you can keep thinking about axons in a familiar way... myelinated projections that send one-way electrical signals). Then whenever that sensor is activated, electrical signals rush towards the spine. It just happens that on their way, these impulses can briefly depolarize the cell body too. But basically they just keep flowing towards the spine. After the signal passes the soma it's back to being a dogmatic axon. Niubrad ( talk) 10:26, 26 January 2018 (UTC)
This publication gives insight on how non-peptidergic primary afferent neurons are involved in pain signaling: Saeed and Ribeiro-da-Silva Molecular Pain 2012, 8:64 Pain-related (nociceptive) information is carried from the periphery to the dorsal horn of the spinal cord mostly by two populations of small diameter primary afferents, the peptidergic and the non-peptidergic. The peptidergic population expresses neuropeptides, such as substance P and calcitonin gene-related peptide, while the non-peptidergic fibers are devoid of neuropeptides, express the purinergic receptor P2X3, and bind the isolectin B4. Pshuster ( talk) 16:30, 16 December 2012 (UTC)
"The majority of these are unipolar neurons in that they have a single axon leaving the cell body and is sent towards the sensory organ." Don't most sorts of neurons have a single axon? Should it say "a single neurite"? Also "and is sent towards the sensory organ" is poor English. Better would be a new sentence "This axon/neurite extends towards the sensory organ". Also the paragraph before the one with this sentence says that afferent neurons are pseudounipolar, which agrees with the illustration. So which is it? Theodore.norvell ( talk) 16:12, 11 November 2013 (UTC)
Would this not be better at Sensory nerve fiber? Is "afferent" somehow more precise? LeadSongDog come howl! 13:17, 8 April 2014 (UTC)
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I'm concerned about the figure, which seems to suggest that sensory neurons from the skin typically terminate in the spinal column. As far as I am aware, the vast majority project to the brain, with the first connection occurring in the cuneate nucleus. 82.230.75.45 21:36, 11 July 2016 (UTC)
Question 1. Is there a single long fiber that goes from the skin to the brain?
Answer: No. Sensory neurons make synaptic connections to spinal cord interneurons which, in turn, form myelinated fiber bundles that project to the brain.
Question 2. What is the anatomy of a sensory neuron?
Answer: Note this is a simplification, but in general... Sensory neurons have cell bodies in the dorsal root ganglion (see Figure-1). These neurons are considered pseudounipolar (see Figure-2). You can think of this unique subtype as consisting of just one long axon, that happens to have a cell body transit station smack-in-the-middle. That is, the axon starts at the skin, and is connected to some specialized sensor (now that might sound like a dendrite, so if it helps, just think of the sensor filling the role of the dendrite, so then you can keep thinking about axons in a familiar way... myelinated projections that send one-way electrical signals). Then whenever that sensor is activated, electrical signals rush towards the spine. It just happens that on their way, these impulses can briefly depolarize the cell body too. But basically they just keep flowing towards the spine. After the signal passes the soma it's back to being a dogmatic axon. Niubrad ( talk) 10:26, 26 January 2018 (UTC)
This publication gives insight on how non-peptidergic primary afferent neurons are involved in pain signaling: Saeed and Ribeiro-da-Silva Molecular Pain 2012, 8:64 Pain-related (nociceptive) information is carried from the periphery to the dorsal horn of the spinal cord mostly by two populations of small diameter primary afferents, the peptidergic and the non-peptidergic. The peptidergic population expresses neuropeptides, such as substance P and calcitonin gene-related peptide, while the non-peptidergic fibers are devoid of neuropeptides, express the purinergic receptor P2X3, and bind the isolectin B4. Pshuster ( talk) 16:30, 16 December 2012 (UTC)
"The majority of these are unipolar neurons in that they have a single axon leaving the cell body and is sent towards the sensory organ." Don't most sorts of neurons have a single axon? Should it say "a single neurite"? Also "and is sent towards the sensory organ" is poor English. Better would be a new sentence "This axon/neurite extends towards the sensory organ". Also the paragraph before the one with this sentence says that afferent neurons are pseudounipolar, which agrees with the illustration. So which is it? Theodore.norvell ( talk) 16:12, 11 November 2013 (UTC)
Would this not be better at Sensory nerve fiber? Is "afferent" somehow more precise? LeadSongDog come howl! 13:17, 8 April 2014 (UTC)
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I have just modified one external link on Afferent nerve fiber. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
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Cheers.— InternetArchiveBot ( Report bug) 14:48, 27 June 2017 (UTC)