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Perhaps this page should be generalized to the study of all adducts, then give DNA adducts as an example?
User:BobBagwill
Definition
I have made clear improvements to the subject, well referenced, and accurate. Prior to that much was unsubstantiated, and very limited in scope. The current version, Adductome, needs work too (e.g., the definition of exposome and therefore origin of the adductome is incorrect).
RedoxStress (
talk)
17:36, 21 August 2023 (UTC)}}reply
@
RedoxStress:. Thanks for your edits. I am not an expert in this field, but there seems to be a range of definitions on what the adductome includes. The narrowest definition is adducts formed between endogenous and exogenous substances. An intermediate definition also includes adducts between endogenous substances and endogenous substance activated by oxidation (i.e., reactive oxygen species) (please note that
PMID35190722 does not mention adductome). The broadest definition would also include any molecule that is the product of biosynthesis including proteins and nucleic acids. I propose that we introduce a cascade of definitions from narrow to broad. Does this sound reasonable?
Boghog (
talk)
19:25, 21 August 2023 (UTC)reply
Really the most precise (and simplest) definition of the adductome is the totality of adducts (akin to genome, proteome etc.). From where these adducts arise i.e., endogenous vs. exogenous, is a different question, and doesn't influence the definition. I'd suggest keeping the definition simple, and describing the origin of adducts separately. OK?
Adductome is part of the WikiProject Biology, an effort to build a comprehensive and detailed guide to
biology on Wikipedia. Leave messages on the WikiProject
talk page.BiologyWikipedia:WikiProject BiologyTemplate:WikiProject BiologyBiology articles
This article is within the scope of WikiProject Science, a collaborative effort to improve the coverage of
Science on Wikipedia. If you would like to participate, please visit the project page, where you can join
the discussion and see a list of open tasks.ScienceWikipedia:WikiProject ScienceTemplate:WikiProject Sciencescience articles
Perhaps this page should be generalized to the study of all adducts, then give DNA adducts as an example?
User:BobBagwill
Definition
I have made clear improvements to the subject, well referenced, and accurate. Prior to that much was unsubstantiated, and very limited in scope. The current version, Adductome, needs work too (e.g., the definition of exposome and therefore origin of the adductome is incorrect).
RedoxStress (
talk)
17:36, 21 August 2023 (UTC)}}reply
@
RedoxStress:. Thanks for your edits. I am not an expert in this field, but there seems to be a range of definitions on what the adductome includes. The narrowest definition is adducts formed between endogenous and exogenous substances. An intermediate definition also includes adducts between endogenous substances and endogenous substance activated by oxidation (i.e., reactive oxygen species) (please note that
PMID35190722 does not mention adductome). The broadest definition would also include any molecule that is the product of biosynthesis including proteins and nucleic acids. I propose that we introduce a cascade of definitions from narrow to broad. Does this sound reasonable?
Boghog (
talk)
19:25, 21 August 2023 (UTC)reply
Really the most precise (and simplest) definition of the adductome is the totality of adducts (akin to genome, proteome etc.). From where these adducts arise i.e., endogenous vs. exogenous, is a different question, and doesn't influence the definition. I'd suggest keeping the definition simple, and describing the origin of adducts separately. OK?