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Why doesn't the article mention pralidoxime, diezepan, or norepinephrine as potential remedies for the effects of acetylcholinesterase inhibitors? - 2-16 15:03, 30 May 2007 (UTC)
I was reading http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-us-brain-power-drugs and it mentioned cholinesterase inhibitors as a coming big thing in nootropics, but I was a little puzzled.
Choline supplements of various stripes have been available for a very long time, and I understood that they worked by encouraging choline->acetylcholine, and acetylcholinesterase works by destroying acetylcholine; so wouldn't the end-goal of choline supplementation and acetylcholinesterase inhibition be the same: a rise in acetylcholine? Why then the interest? -- 129.49.7.125 ( talk) 21:33, 1 October 2009 (UTC)
Interesting review [1] -- Doc James ( talk · contribs · email) 15:37, 30 April 2011 (UTC)
Supplements inhibiting Acetylcholinesterase include
Such supplements, as well as Huperzine etc., share many of the side effects of pharmaceutical acetylcholinesterase inhibitors.
Ocdnctx ( talk) 18:29, 28 April 2013 (UTC)
I think it is worth having an effects section of this article. The side effects covers unintended consequences, possibly reflecting a a smaller or chronic dose. And uses section is the practical realization of intended effects. But the direct consequences of intended use are not listed here. This would be the consequences to a prey organism of a spider bite (paralysis) or the use of a chemical weapon. Dbsseven ( talk) 19:58, 14 March 2018 (UTC)
Are there any examples of acetylcholinesterase partial inhibitors known?
(An enzyme partial inhibitor is a substance that reduces the speed at which the enzyme catalyzes the reaction of its substrate, but it does not disable the enzyme completely even at high concentration. This means, an ACHE partial inhibitor would slow down cholinergic transmission, but not as extremely as a complete inhibitor.) -- 79.240.205.49 ( talk) 00:30, 9 August 2018 (UTC)
This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||||||
|
Why doesn't the article mention pralidoxime, diezepan, or norepinephrine as potential remedies for the effects of acetylcholinesterase inhibitors? - 2-16 15:03, 30 May 2007 (UTC)
I was reading http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-us-brain-power-drugs and it mentioned cholinesterase inhibitors as a coming big thing in nootropics, but I was a little puzzled.
Choline supplements of various stripes have been available for a very long time, and I understood that they worked by encouraging choline->acetylcholine, and acetylcholinesterase works by destroying acetylcholine; so wouldn't the end-goal of choline supplementation and acetylcholinesterase inhibition be the same: a rise in acetylcholine? Why then the interest? -- 129.49.7.125 ( talk) 21:33, 1 October 2009 (UTC)
Interesting review [1] -- Doc James ( talk · contribs · email) 15:37, 30 April 2011 (UTC)
Supplements inhibiting Acetylcholinesterase include
Such supplements, as well as Huperzine etc., share many of the side effects of pharmaceutical acetylcholinesterase inhibitors.
Ocdnctx ( talk) 18:29, 28 April 2013 (UTC)
I think it is worth having an effects section of this article. The side effects covers unintended consequences, possibly reflecting a a smaller or chronic dose. And uses section is the practical realization of intended effects. But the direct consequences of intended use are not listed here. This would be the consequences to a prey organism of a spider bite (paralysis) or the use of a chemical weapon. Dbsseven ( talk) 19:58, 14 March 2018 (UTC)
Are there any examples of acetylcholinesterase partial inhibitors known?
(An enzyme partial inhibitor is a substance that reduces the speed at which the enzyme catalyzes the reaction of its substrate, but it does not disable the enzyme completely even at high concentration. This means, an ACHE partial inhibitor would slow down cholinergic transmission, but not as extremely as a complete inhibitor.) -- 79.240.205.49 ( talk) 00:30, 9 August 2018 (UTC)