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I'm not sufficiently knowledgeable in organic chemistry to decide whether this is a lipid or not. I do know that it is described as a lipid (repeatedly) in the MHRA source (Medicines and Healthcare products Regulatory Agency (11 December 2020). "Public Assessment Report: Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2" (PDF).). It is introduced thus therein:
Both ALC-0315 and ALC-0159 are repeatedly characterised as lipids. As for esters and amines, I find only this characterisation:
@ Graeme Bartlett: You categorised this article in Category:Esters and Category:Amines only. Neither is a subcategory of Category:Lipids. I suppose that at least some subcategory of the esters could be made a subcategory of lipids, too; from a quick browse of the article Ester I suspect that Category:Glycerol esters would be a candidate for such a double categorisation. Pending this, and placing these two ALC's in some such category, I put them directly into Category:Lipids, without removing any existing categorisation.
As I wrote, I'm extremely unsure about the factual correctness of this; I just lean on my interpretation of the MHRA ('reliable') source. If I'm wrong, then just revert. JoergenB ( talk) 21:50, 30 January 2021 (UTC)
In my opinion, anything about muscle cells (specifically) in relation to transfection should be removed from the page. The actual target for transfection are antigen-presenting cells, as described here: [1], but other cell types could be transfected as well: [2].
References
My understanding is that whilst this substance has been approved for research purposes in medicine and pharmaceutics, that there is actually no authorisation of this substance on use in humans (and the same for ALC-0159 - the other aspect of nanotechnology introduced in the Pfizer Vaccine). I've not been able to source any studies, abstracts, peer-reviewed publications or scholarly articles on its use in humans, its side-effects, and understand it can be toxic. As far as my understanding goes, the FDA approved its use within the vaccine without the correct PK studies (or any on these particular substances), nor was any toxicity/carcinogenicity testing done, and without these substances otherwise being tested for safety in humans. This is, of course, very concerning when it's been a very opaque process from start to finish, and with pfizer wishing to withhold data, unethically and unnecessarily (provided there's nothing to hide, of course). Perhaps you can investigate and get something noted about it here. My understanding of these substances is that theu shouldn't be being administered into human bodies... the fact they are, when last year at the annual World Economic Forum meeting (2020), a speech was done on how we need to " accept that we are no longer mysterious souls, but instead, "hackable animals ". Grossly concerning... with it being announced that Dr Fauci and Dr Baric misrepresented information entirely to the public, gain of function WAS funded and carried out when they said it wasn't, and the push for these vaccines to be taken without the correct testing and data... it's all too much. Wikipedia is massively used by many. Please look into this with me and help people like me to act on it... what is happening in the world is not ok. 2A02:C7F:3B81:A200:3D84:7E79:59FF:50FA ( talk) 14:03, 23 December 2021 (UTC)
The investigative collective Correctiv asked the European Medicines Agency (EMA) on the safety of ALC-0315 and ALC-0159 and quoted the answer from the EMA:
"By entering the blood stream, lipid nanoparticles can come into contact (fuse) with many types of cells in the body and distribute the mRNA to different tissues. Animal models have been used to study how the components of the vaccine distribute to tissues other than the muscle into which they are injected.
These studies used much higher doses of vaccine to investigate its safety and found that the components, the mRNA and lipid nanoparticles, remain mainly at the injection site, with only small amounts able to reach other tissues, such as the liver. These studies give confidence that when vaccines are given to humans, no safety problems due to accumulation of lipid nanoparticles and mRNA in other tissues are expected." [1] (access-date: 2022-01-23) -- Myosci ( talk) 11:22, 23 January 2022 (UTC)
![]() | This article is rated Start-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | ||||||||||||||||||||||||||||||
|
I'm not sufficiently knowledgeable in organic chemistry to decide whether this is a lipid or not. I do know that it is described as a lipid (repeatedly) in the MHRA source (Medicines and Healthcare products Regulatory Agency (11 December 2020). "Public Assessment Report: Authorisation for Temporary Supply COVID-19 mRNA Vaccine BNT162b2" (PDF).). It is introduced thus therein:
Both ALC-0315 and ALC-0159 are repeatedly characterised as lipids. As for esters and amines, I find only this characterisation:
@ Graeme Bartlett: You categorised this article in Category:Esters and Category:Amines only. Neither is a subcategory of Category:Lipids. I suppose that at least some subcategory of the esters could be made a subcategory of lipids, too; from a quick browse of the article Ester I suspect that Category:Glycerol esters would be a candidate for such a double categorisation. Pending this, and placing these two ALC's in some such category, I put them directly into Category:Lipids, without removing any existing categorisation.
As I wrote, I'm extremely unsure about the factual correctness of this; I just lean on my interpretation of the MHRA ('reliable') source. If I'm wrong, then just revert. JoergenB ( talk) 21:50, 30 January 2021 (UTC)
In my opinion, anything about muscle cells (specifically) in relation to transfection should be removed from the page. The actual target for transfection are antigen-presenting cells, as described here: [1], but other cell types could be transfected as well: [2].
References
My understanding is that whilst this substance has been approved for research purposes in medicine and pharmaceutics, that there is actually no authorisation of this substance on use in humans (and the same for ALC-0159 - the other aspect of nanotechnology introduced in the Pfizer Vaccine). I've not been able to source any studies, abstracts, peer-reviewed publications or scholarly articles on its use in humans, its side-effects, and understand it can be toxic. As far as my understanding goes, the FDA approved its use within the vaccine without the correct PK studies (or any on these particular substances), nor was any toxicity/carcinogenicity testing done, and without these substances otherwise being tested for safety in humans. This is, of course, very concerning when it's been a very opaque process from start to finish, and with pfizer wishing to withhold data, unethically and unnecessarily (provided there's nothing to hide, of course). Perhaps you can investigate and get something noted about it here. My understanding of these substances is that theu shouldn't be being administered into human bodies... the fact they are, when last year at the annual World Economic Forum meeting (2020), a speech was done on how we need to " accept that we are no longer mysterious souls, but instead, "hackable animals ". Grossly concerning... with it being announced that Dr Fauci and Dr Baric misrepresented information entirely to the public, gain of function WAS funded and carried out when they said it wasn't, and the push for these vaccines to be taken without the correct testing and data... it's all too much. Wikipedia is massively used by many. Please look into this with me and help people like me to act on it... what is happening in the world is not ok. 2A02:C7F:3B81:A200:3D84:7E79:59FF:50FA ( talk) 14:03, 23 December 2021 (UTC)
The investigative collective Correctiv asked the European Medicines Agency (EMA) on the safety of ALC-0315 and ALC-0159 and quoted the answer from the EMA:
"By entering the blood stream, lipid nanoparticles can come into contact (fuse) with many types of cells in the body and distribute the mRNA to different tissues. Animal models have been used to study how the components of the vaccine distribute to tissues other than the muscle into which they are injected.
These studies used much higher doses of vaccine to investigate its safety and found that the components, the mRNA and lipid nanoparticles, remain mainly at the injection site, with only small amounts able to reach other tissues, such as the liver. These studies give confidence that when vaccines are given to humans, no safety problems due to accumulation of lipid nanoparticles and mRNA in other tissues are expected." [1] (access-date: 2022-01-23) -- Myosci ( talk) 11:22, 23 January 2022 (UTC)