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The article writes:"PAS is manufactured by the carboxylation of 3-aminophenol.[6]"
Well PAS is produced in two steps.One is reaction of 3-aminophenol with CO2 and sodium hydroxide, in a process very similar to the production of Salicylic acid:
3-aminophenol + CO2 + NaOH ----->Product 1.This reaction is did under hight temperatures and pressions.
Product 1 + H2SO4 -----> 4-Aminosalicylic acid + Na2SO4(sodium sulfate). sodium sulfate is separeted using organic product such as ethanol or ether. Agre22 ( talk) 22:21, 11 January 2010 (UTC)agre22
Isn't the space filling model missing a hydrogen, specifically in the carboxylic acid group? 203.97.134.50 ( talk) 22:10, 25 June 2012 (UTC)
Debates about priority can be complicated, but I feel that some gesture should be made in the direction of the various claims made re PAS & streptomycin. I have been reading "Tuberculosis: the Greatest Story Never Told", Frank Ryan, Swift, 1992. p256: "On 30 and 31 October, 1944, a month before the young woman from Austin was given the first treatment with streptomycin for pulmonary tuberculosis, in Gothenburg, Sweden, Sigrid received her first cautious dose of PAS by mouth ... ". It seems that although human trials of PAS preceded those with streptomycin, the former drug was accepted more cautiously by the medical profession, and therefore the impression has arisen that Streptomycin had priority. It might be justifiable to say that Streptomycin was the first widely used anti tubercular drug, but PAS was apparently the first truly effective drug to be used. g4oep — Preceding unsigned comment added by 77.96.60.31 ( talk) 09:16, 31 October 2014 (UTC)
Is the structural model correct ? I can see only 6 hydrogen atoms. Compare the picture in the article with this:
g4oep — Preceding unsigned comment added by 77.96.60.31 ( talk) 09:27, 31 October 2014 (UTC)
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The article writes:"PAS is manufactured by the carboxylation of 3-aminophenol.[6]"
Well PAS is produced in two steps.One is reaction of 3-aminophenol with CO2 and sodium hydroxide, in a process very similar to the production of Salicylic acid:
3-aminophenol + CO2 + NaOH ----->Product 1.This reaction is did under hight temperatures and pressions.
Product 1 + H2SO4 -----> 4-Aminosalicylic acid + Na2SO4(sodium sulfate). sodium sulfate is separeted using organic product such as ethanol or ether. Agre22 ( talk) 22:21, 11 January 2010 (UTC)agre22
Isn't the space filling model missing a hydrogen, specifically in the carboxylic acid group? 203.97.134.50 ( talk) 22:10, 25 June 2012 (UTC)
Debates about priority can be complicated, but I feel that some gesture should be made in the direction of the various claims made re PAS & streptomycin. I have been reading "Tuberculosis: the Greatest Story Never Told", Frank Ryan, Swift, 1992. p256: "On 30 and 31 October, 1944, a month before the young woman from Austin was given the first treatment with streptomycin for pulmonary tuberculosis, in Gothenburg, Sweden, Sigrid received her first cautious dose of PAS by mouth ... ". It seems that although human trials of PAS preceded those with streptomycin, the former drug was accepted more cautiously by the medical profession, and therefore the impression has arisen that Streptomycin had priority. It might be justifiable to say that Streptomycin was the first widely used anti tubercular drug, but PAS was apparently the first truly effective drug to be used. g4oep — Preceding unsigned comment added by 77.96.60.31 ( talk) 09:16, 31 October 2014 (UTC)
Is the structural model correct ? I can see only 6 hydrogen atoms. Compare the picture in the article with this:
g4oep — Preceding unsigned comment added by 77.96.60.31 ( talk) 09:27, 31 October 2014 (UTC)
Hello fellow Wikipedians,
I have just modified 2 external links on 4-Aminosalicylic acid. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:
When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
This message was posted before February 2018.
After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than
regular verification using the archive tool instructions below. Editors
have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
RfC before doing mass systematic removals. This message is updated dynamically through the template {{
source check}}
(last update: 5 June 2024).
Cheers.— InternetArchiveBot ( Report bug) 21:51, 22 June 2017 (UTC)