This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about 25I-NBOMe.
|
Given the "Citation Needed" note <ref name=undefined /> regarding dose and a recent delve into the pharmacological effects of this psychoactive chemical I wish to ask: is Erowid's report on a quite similar chemical enough? Their claims could easily be substantiated by a layman but at this time you will not find a true pharmacological report from any "Reputable" source. I say it gets dropped, the citation needed note removed given that the molecules are so similar (Merely a switched Chloride group for a iodine.) Dosage between the 2C-? series doesn't shift significantly (With modification of the 4'th location of the benzene ring, not the addition of an advanced group at the 1st) because they are all relatively the same, as is the DO? series. The 25?-NBOMe series will take a few months, even years to undergo reputable research but there are many people who have experimented with this chemical and have reported the dosage within this range. I don't think it's justifiable to state citation needed when you'll find no better source for quite some time as Erowid.
http://www.erowid.org/chemicals/nbome/nbome_effects.shtml — Preceding unsigned comment added by 64.142.74.180 ( talk) 15:02, 6 January 2012 (UTC) Agreed, erowid is perfectly acceptable as a reference. Testem ( talk) 12:42, 14 July 2014 (UTC)
This compound reported in Virginia as cause for at least 5 overdoses. Our poison control center issued a warning on this drug. Suggest not delete as many may be looking for more info on this drug if overdoses continue. — Preceding unsigned comment added by 199.87.130.129 ( talk) 15:08, 12 March 2012 (UTC)
In “ http://en.wikipedia.org/wiki/25I-NBOMe“ there is given a Ki = 0.044 nM for 25I-NBOMe. This Ki is obtained from (h5-HT2A)-experiments, making 25I-NBOMe some sixteen times the potency of 2C-I (Ki = 0.73 nM) itself.(see ref.)
In “ http://en.wikipedia.org/wiki/25I-NBOH” a Ki = 0.12 nM is given for 25I-NBOH. But this Ki is derived from (r5-HT2A)-experiments and therefore can not directly be compared with the Ki given for 25I-NBOMe. The Ki for 25I-NBOH derived from (h5-HT2A)-experiments is 0.061 nM, making 25I-NBOH some twelve times the potency of 2C-I (Ki = 0.73 nM) itself.(see ref.)
Other Ki-values within the phenyethylamine-N-benzy-series reported in en.wikipedia.org may derived also from different experiments and could therefore not compared directly. I was not able to control this.
ref.: Molecular Pharmacology Fast Forward. Published on September 25, 2006 as doi:10.1124/mol.106.028720 Copyright 2006 Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with super-potent N-benzyl phenethylamine agonists. Michael R. Braden, Jason C. Parrish, John C. Naylor, David E. Nichols Department of Medicinal Chemistry and Molecular Pharmacology School of Pharmacy and Pharmaceutical Sciences Purdue University, West Lafayette, IN 47907 Anna Bolaine ( talk) 14:33, 11 April 2012 (UTC)
The title is seriously messed up. At least add redirects (I would but I don't know how to) for "25-I" and "N-Bomb" I was looking for this article but came up empty with those two phrases (after reading this article: http://www.nola.com/crime/index.ssf/2012/11/21-year-old_dies_after_one_dro.html#incart_m-rpt-2), but lucked onto it by doing a Google search for "25-I" which brought me back to Wikipedia. Br77rino ( talk) 22:58, 2 November 2012 (UTC)
It is suspicious that there are no other sources for a story of such a pertinent ill about a drug that is legal in most places in a culture that wants to ban drugs. I have strong suspicions the stories are invented. When there is no consistency across sources with such a culturally powerful story it usually means nobody else could verify it, and the source we have thus probably invented it or not done fact checking themselves for evidence of the reports being true.
Further, I find it unlikely this drug has killed anyone, there is no lethality with the 2C drugs it is derivative from. It would take extremely high non-recreational doses. There is the possibility that someone effected by the drug thought it was a good idea to ingest a legal amount. I still don't think this is encyclopedia story without consistency across sources, details to such a story as my theory, or details about what the dosage was, along with details about the MLD50.
There is no law preventing this from rat's so the further possibility remains that there is no lethal dose. -- Johnubis ( talk) 00:51, 25 May 2013 (UTC)
Right now, as I see it, the lead paragraph consists largely of information contained no where else in the article, rather than as a stand-alone summary. (See WP:Lead: "The lead should be able to stand alone as a concise overview. It should define the topic, establish context, explain why the topic is notable, and summarize the most important points—including any prominent controversies.") No where else in the article is the origin or research value of 25I explicated, and I worry that their current prominence in the lead gives them undue weight.
Does anyone else share this view? I'll start to reform the lead (and incorporate some of the synthesis information into the body of the article) in the mean time. Mnation2 ( talk) 21:39, 16 June 2013 (UTC)
Here's a great source on the chemistry of the compound, with a little bit of general overview, if anyone is familiar enough with the subject material to incorporate it: http://www.justice.gov/dea/pr/microgram-journals/2012/mj9_84-109.pdf
Exercisephys ( talk) 18:52, 22 July 2013 (UTC)
25I-NBOME is, without question, a neurotoxic hallucinogen. The tone of the article is far too inviting. I don't mean to be alarmist but quoting erowid's doses and saying nothing more about the LD50 (even speculation) is bad policy. I recommend listing 15-20 micrograms per kilogram as an approximate LD50 and listing this substance as a neurotoxin in the opening paragraph, for the sake of harm reduction. It would also be pertinant to discuss in more depth the misrepresentation of this compound as LSD, as this almost certainly leads to overdose or other injury. RotogenRay ( talk) 17:54, 21 April 2014 (UTC)
Hello, I came to this page to find out if 25I-NBOMe deaths are from being poisoned by the drug itself (overdose) or from fatal behavior due to being high while on the drug. I still don't know, but would love to, if someone can clear that up. 116.90.80.201 ( talk) 04:57, 8 October 2015 (UTC)
@ 3AlarmLampscooter:I think the "66 times" comparison could be misleading as it only concerns one receptor. What made you want to phrase it like this? Do you think it would be better to simply state LSD's affinity? This would also not be OR :p Testem ( talk) 09:06, 2 June 2014 (UTC)
the direct reference, says in Hebrew, that only 25I-NBOME became illegal. that's it. not the whole series where do they get it? for dummies who won't bother going to the reference page, here it is, focus on page 4 of the pdf. http://www.health.gov.il/LegislationLibrary/25574413.pdf hope you change the facts as it's dishonest and unprofessional to leave it like that for so long without verifying. tnx — Preceding unsigned comment added by 84.109.37.236 ( talk) 02:26, 13 July 2014 (UTC)
As you know, there's a lot of news recently about 25I-NBOMe being sold as LSD and people having very bad trips. Should fake LSD be mentioned in the lede? Fake LSD is a popular search term, therefor I created a redirect "Fake LSD" to this article. Raquel Baranow ( talk) 16:58, 27 February 2016 (UTC)
Listing the Ki values over 500nM is a little bit deceptive to the average reader. Lower Ki = higher affinity (Ki is the concentration of molecule needed to "fill up" half of the receptors, so if it takes fewer molecules, then it has a higher affinity). I believe the intention was to list receptors with a high affinity, therefore, Ki's lower than 500nM are more relevant and should have been listed. From source: "Ki values (nM) for receptors where it had significant affinity: 5-HT2C (2); 5HT6 (73 ± 12); μ opiate (82 ± 14); H1 (189 ± 35); 5-HT2B (231 ± 73); kappa opiate (288 ± 50)." should be listed instead (or at least along with).
2ndly I noticed the source article is about a demethylated form of the molecule. I would sure hope this is the known product after biological breakdown if it's being used as a source of info for this article. Otherwise, why reference it at all? — Preceding unsigned comment added by Syntheticorganics ( talk • contribs) 21:05, 16 March 2016 (UTC)
The article says that it is rumored to be orally inactive. This is plain and simply not true. In fact, it seems to me that it is best to keep it in the mouth for quite a while, or else it will not be as active. I have no sources for this, except my own experimentation. Therefore I will just type it here, in the talk-section, and hope that people that need this knowledge might find it. — Preceding unsigned comment added by 185.213.154.253 ( talk) 14:52, 21 April 2019 (UTC)
As you can see I have changed the name "wizard" to "wizard medication". There are no identifiable instances of this compound being referred to simply as Wizard. Clearly, "Wizard Medication" is a noun phrase, with "Wizard" acting as an adjectival lexeme altering the noun "Medication". The implication, thus, is that 25i-nbome is used as a cure for not being enough of a wizard. The term is a "play on words"; insinuating that 25i-nBome qualifies legitimate medication prescribed by ones primary health provider. It's what's known in common circles as a "joke" comparing what is effectively a purely recreational drug with an important, perhaps even life-saving medication. Thanks. Please stop referring to the term Wizard Medication as a slang term when the other "street names" provided are just little-known and flimsily cited. A drug's "street name" isn't exactly a matter for peer review - if one has heard the term on the street perhaps it is then a given that it counts as a "Street Name". Given that perhaps fewer than half of the people editing this page have even been in the same room as the drug, perhaps don't presume to know everything about the parlance surrounded. — Preceding unsigned comment added by 86.30.144.3 ( talk) 17:00, 25 April 2020 (UTC)
"25I-NBOMe acts as a highly potent full agonist for the human 5-HT2A receptor,[30][32] with a dissociation constant (Kd) of 0.044 nM, making it some sixteen times the potency of 2C-I itself at this receptor."
Why "itself"? 2C-I is not the endogenous ligand of the 5-HT2A receptor. -- 46.91.52.88 ( talk) 20:44, 12 June 2021 (UTC)
Would be interesting to have more info on the research side of this substance and not just recreational drug use and basic chemistry info. Gives the impression that the main intent of the article is to talk about use/abuse and not broad info, when the drug was invented to map the 5-HT2A receptor in the first place. 2605:B100:B2A:F6:F0D3:561B:42BB:392B ( talk) 12:09, 29 April 2024 (UTC)
This article is rated C-class on Wikipedia's
content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||
|
Ideal sources for Wikipedia's health content are defined in the guideline
Wikipedia:Identifying reliable sources (medicine) and are typically
review articles. Here are links to possibly useful sources of information about 25I-NBOMe.
|
Given the "Citation Needed" note <ref name=undefined /> regarding dose and a recent delve into the pharmacological effects of this psychoactive chemical I wish to ask: is Erowid's report on a quite similar chemical enough? Their claims could easily be substantiated by a layman but at this time you will not find a true pharmacological report from any "Reputable" source. I say it gets dropped, the citation needed note removed given that the molecules are so similar (Merely a switched Chloride group for a iodine.) Dosage between the 2C-? series doesn't shift significantly (With modification of the 4'th location of the benzene ring, not the addition of an advanced group at the 1st) because they are all relatively the same, as is the DO? series. The 25?-NBOMe series will take a few months, even years to undergo reputable research but there are many people who have experimented with this chemical and have reported the dosage within this range. I don't think it's justifiable to state citation needed when you'll find no better source for quite some time as Erowid.
http://www.erowid.org/chemicals/nbome/nbome_effects.shtml — Preceding unsigned comment added by 64.142.74.180 ( talk) 15:02, 6 January 2012 (UTC) Agreed, erowid is perfectly acceptable as a reference. Testem ( talk) 12:42, 14 July 2014 (UTC)
This compound reported in Virginia as cause for at least 5 overdoses. Our poison control center issued a warning on this drug. Suggest not delete as many may be looking for more info on this drug if overdoses continue. — Preceding unsigned comment added by 199.87.130.129 ( talk) 15:08, 12 March 2012 (UTC)
In “ http://en.wikipedia.org/wiki/25I-NBOMe“ there is given a Ki = 0.044 nM for 25I-NBOMe. This Ki is obtained from (h5-HT2A)-experiments, making 25I-NBOMe some sixteen times the potency of 2C-I (Ki = 0.73 nM) itself.(see ref.)
In “ http://en.wikipedia.org/wiki/25I-NBOH” a Ki = 0.12 nM is given for 25I-NBOH. But this Ki is derived from (r5-HT2A)-experiments and therefore can not directly be compared with the Ki given for 25I-NBOMe. The Ki for 25I-NBOH derived from (h5-HT2A)-experiments is 0.061 nM, making 25I-NBOH some twelve times the potency of 2C-I (Ki = 0.73 nM) itself.(see ref.)
Other Ki-values within the phenyethylamine-N-benzy-series reported in en.wikipedia.org may derived also from different experiments and could therefore not compared directly. I was not able to control this.
ref.: Molecular Pharmacology Fast Forward. Published on September 25, 2006 as doi:10.1124/mol.106.028720 Copyright 2006 Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with super-potent N-benzyl phenethylamine agonists. Michael R. Braden, Jason C. Parrish, John C. Naylor, David E. Nichols Department of Medicinal Chemistry and Molecular Pharmacology School of Pharmacy and Pharmaceutical Sciences Purdue University, West Lafayette, IN 47907 Anna Bolaine ( talk) 14:33, 11 April 2012 (UTC)
The title is seriously messed up. At least add redirects (I would but I don't know how to) for "25-I" and "N-Bomb" I was looking for this article but came up empty with those two phrases (after reading this article: http://www.nola.com/crime/index.ssf/2012/11/21-year-old_dies_after_one_dro.html#incart_m-rpt-2), but lucked onto it by doing a Google search for "25-I" which brought me back to Wikipedia. Br77rino ( talk) 22:58, 2 November 2012 (UTC)
It is suspicious that there are no other sources for a story of such a pertinent ill about a drug that is legal in most places in a culture that wants to ban drugs. I have strong suspicions the stories are invented. When there is no consistency across sources with such a culturally powerful story it usually means nobody else could verify it, and the source we have thus probably invented it or not done fact checking themselves for evidence of the reports being true.
Further, I find it unlikely this drug has killed anyone, there is no lethality with the 2C drugs it is derivative from. It would take extremely high non-recreational doses. There is the possibility that someone effected by the drug thought it was a good idea to ingest a legal amount. I still don't think this is encyclopedia story without consistency across sources, details to such a story as my theory, or details about what the dosage was, along with details about the MLD50.
There is no law preventing this from rat's so the further possibility remains that there is no lethal dose. -- Johnubis ( talk) 00:51, 25 May 2013 (UTC)
Right now, as I see it, the lead paragraph consists largely of information contained no where else in the article, rather than as a stand-alone summary. (See WP:Lead: "The lead should be able to stand alone as a concise overview. It should define the topic, establish context, explain why the topic is notable, and summarize the most important points—including any prominent controversies.") No where else in the article is the origin or research value of 25I explicated, and I worry that their current prominence in the lead gives them undue weight.
Does anyone else share this view? I'll start to reform the lead (and incorporate some of the synthesis information into the body of the article) in the mean time. Mnation2 ( talk) 21:39, 16 June 2013 (UTC)
Here's a great source on the chemistry of the compound, with a little bit of general overview, if anyone is familiar enough with the subject material to incorporate it: http://www.justice.gov/dea/pr/microgram-journals/2012/mj9_84-109.pdf
Exercisephys ( talk) 18:52, 22 July 2013 (UTC)
25I-NBOME is, without question, a neurotoxic hallucinogen. The tone of the article is far too inviting. I don't mean to be alarmist but quoting erowid's doses and saying nothing more about the LD50 (even speculation) is bad policy. I recommend listing 15-20 micrograms per kilogram as an approximate LD50 and listing this substance as a neurotoxin in the opening paragraph, for the sake of harm reduction. It would also be pertinant to discuss in more depth the misrepresentation of this compound as LSD, as this almost certainly leads to overdose or other injury. RotogenRay ( talk) 17:54, 21 April 2014 (UTC)
Hello, I came to this page to find out if 25I-NBOMe deaths are from being poisoned by the drug itself (overdose) or from fatal behavior due to being high while on the drug. I still don't know, but would love to, if someone can clear that up. 116.90.80.201 ( talk) 04:57, 8 October 2015 (UTC)
@ 3AlarmLampscooter:I think the "66 times" comparison could be misleading as it only concerns one receptor. What made you want to phrase it like this? Do you think it would be better to simply state LSD's affinity? This would also not be OR :p Testem ( talk) 09:06, 2 June 2014 (UTC)
the direct reference, says in Hebrew, that only 25I-NBOME became illegal. that's it. not the whole series where do they get it? for dummies who won't bother going to the reference page, here it is, focus on page 4 of the pdf. http://www.health.gov.il/LegislationLibrary/25574413.pdf hope you change the facts as it's dishonest and unprofessional to leave it like that for so long without verifying. tnx — Preceding unsigned comment added by 84.109.37.236 ( talk) 02:26, 13 July 2014 (UTC)
As you know, there's a lot of news recently about 25I-NBOMe being sold as LSD and people having very bad trips. Should fake LSD be mentioned in the lede? Fake LSD is a popular search term, therefor I created a redirect "Fake LSD" to this article. Raquel Baranow ( talk) 16:58, 27 February 2016 (UTC)
Listing the Ki values over 500nM is a little bit deceptive to the average reader. Lower Ki = higher affinity (Ki is the concentration of molecule needed to "fill up" half of the receptors, so if it takes fewer molecules, then it has a higher affinity). I believe the intention was to list receptors with a high affinity, therefore, Ki's lower than 500nM are more relevant and should have been listed. From source: "Ki values (nM) for receptors where it had significant affinity: 5-HT2C (2); 5HT6 (73 ± 12); μ opiate (82 ± 14); H1 (189 ± 35); 5-HT2B (231 ± 73); kappa opiate (288 ± 50)." should be listed instead (or at least along with).
2ndly I noticed the source article is about a demethylated form of the molecule. I would sure hope this is the known product after biological breakdown if it's being used as a source of info for this article. Otherwise, why reference it at all? — Preceding unsigned comment added by Syntheticorganics ( talk • contribs) 21:05, 16 March 2016 (UTC)
The article says that it is rumored to be orally inactive. This is plain and simply not true. In fact, it seems to me that it is best to keep it in the mouth for quite a while, or else it will not be as active. I have no sources for this, except my own experimentation. Therefore I will just type it here, in the talk-section, and hope that people that need this knowledge might find it. — Preceding unsigned comment added by 185.213.154.253 ( talk) 14:52, 21 April 2019 (UTC)
As you can see I have changed the name "wizard" to "wizard medication". There are no identifiable instances of this compound being referred to simply as Wizard. Clearly, "Wizard Medication" is a noun phrase, with "Wizard" acting as an adjectival lexeme altering the noun "Medication". The implication, thus, is that 25i-nbome is used as a cure for not being enough of a wizard. The term is a "play on words"; insinuating that 25i-nBome qualifies legitimate medication prescribed by ones primary health provider. It's what's known in common circles as a "joke" comparing what is effectively a purely recreational drug with an important, perhaps even life-saving medication. Thanks. Please stop referring to the term Wizard Medication as a slang term when the other "street names" provided are just little-known and flimsily cited. A drug's "street name" isn't exactly a matter for peer review - if one has heard the term on the street perhaps it is then a given that it counts as a "Street Name". Given that perhaps fewer than half of the people editing this page have even been in the same room as the drug, perhaps don't presume to know everything about the parlance surrounded. — Preceding unsigned comment added by 86.30.144.3 ( talk) 17:00, 25 April 2020 (UTC)
"25I-NBOMe acts as a highly potent full agonist for the human 5-HT2A receptor,[30][32] with a dissociation constant (Kd) of 0.044 nM, making it some sixteen times the potency of 2C-I itself at this receptor."
Why "itself"? 2C-I is not the endogenous ligand of the 5-HT2A receptor. -- 46.91.52.88 ( talk) 20:44, 12 June 2021 (UTC)
Would be interesting to have more info on the research side of this substance and not just recreational drug use and basic chemistry info. Gives the impression that the main intent of the article is to talk about use/abuse and not broad info, when the drug was invented to map the 5-HT2A receptor in the first place. 2605:B100:B2A:F6:F0D3:561B:42BB:392B ( talk) 12:09, 29 April 2024 (UTC)