T cell deficiency | |
---|---|
Human T Cell | |
Specialty | Immunology |
Symptoms | Eczematous [1] |
Types | Primary or Secondary [2] |
Diagnostic method | Delayed hypersensitivity skin test, T cell count [1] [3] [4] |
Treatment | Bone marrow transplant, Immunoglobulin replacement [1] [2] |
T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it causes an immunodeficiency of cell-mediated immunity. [1] T cells normal function is to help with the human body's immunity, they are one of the two primary types of lymphocytes(the other being B cells).[ medical citation needed]
Presentations differ among causes, but T cell insufficiency generally manifests as unusually severe common viral infections ( respiratory syncytial virus, rotavirus), diarrhea, and eczematous or erythrodermatous rashes. [1] Failure to thrive and cachexia are later signs of a T-cell deficiency. [1]
In terms of the normal mechanism of T cell we find that it is a type of white blood cell that has an important role in immunity, and is made from thymocytes. [5] One sees in the partial disorder of T cells that happen due to cell signaling defects, are usually caused by hypomorphic gene defects. [6] Generally, (micro)deletion of 22Q11.2 is the most often seen. [7]
The main pathogens of concern in T cell deficiencies are intracellular pathogens, including Herpes simplex virus, Mycobacterium and Listeria. [8] Also, intracellular fungal infections are also more common and severe in T cell deficiencies. [8] Other intracellular pathogens of major concern in T cell deficiency are:
The diagnosis of T cell deficiency can be ascertained in those individuals with this condition via the following: [1] [4] [3]
In terms of the management of T cell deficiency for those individuals with this condition the following can be applied: [2] [1]
In the U.S. this defect occurs in about 1 in 70,000, with the majority of cases presenting in early life. [1] Furthermore, SCID has an incidence of approximately 1 in 66,000 in California. [10]
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T cell deficiency | |
---|---|
Human T Cell | |
Specialty | Immunology |
Symptoms | Eczematous [1] |
Types | Primary or Secondary [2] |
Diagnostic method | Delayed hypersensitivity skin test, T cell count [1] [3] [4] |
Treatment | Bone marrow transplant, Immunoglobulin replacement [1] [2] |
T cell deficiency is a deficiency of T cells, caused by decreased function of individual T cells, it causes an immunodeficiency of cell-mediated immunity. [1] T cells normal function is to help with the human body's immunity, they are one of the two primary types of lymphocytes(the other being B cells).[ medical citation needed]
Presentations differ among causes, but T cell insufficiency generally manifests as unusually severe common viral infections ( respiratory syncytial virus, rotavirus), diarrhea, and eczematous or erythrodermatous rashes. [1] Failure to thrive and cachexia are later signs of a T-cell deficiency. [1]
In terms of the normal mechanism of T cell we find that it is a type of white blood cell that has an important role in immunity, and is made from thymocytes. [5] One sees in the partial disorder of T cells that happen due to cell signaling defects, are usually caused by hypomorphic gene defects. [6] Generally, (micro)deletion of 22Q11.2 is the most often seen. [7]
The main pathogens of concern in T cell deficiencies are intracellular pathogens, including Herpes simplex virus, Mycobacterium and Listeria. [8] Also, intracellular fungal infections are also more common and severe in T cell deficiencies. [8] Other intracellular pathogens of major concern in T cell deficiency are:
The diagnosis of T cell deficiency can be ascertained in those individuals with this condition via the following: [1] [4] [3]
In terms of the management of T cell deficiency for those individuals with this condition the following can be applied: [2] [1]
In the U.S. this defect occurs in about 1 in 70,000, with the majority of cases presenting in early life. [1] Furthermore, SCID has an incidence of approximately 1 in 66,000 in California. [10]
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cite journal}}
: Cite journal requires |journal=
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help)