Testis-specific Y-encoded protein 1 is a
protein that in humans is encoded by the TSPY1gene.[3]
The protein encoded by this gene is found only in testicular tissue and may be involved in
spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional
orthologous gene is found in
mice. Two transcript variants encoding different isoforms have been found for this gene.[4] The protein is strongly overexpressed in
gonadoblastoma.[5]
Vogel T, Schmidtke J (1998). "Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein"". Cytogenet. Cell Genet. 80 (1–4): 209–13.
doi:
10.1159/000014982.
PMID9678360.
S2CID46875273.
Zhang JS, Yang-Feng TL, Muller U, et al. (1993). "Molecular isolation and characterization of an expressed gene from the human Y chromosome". Hum. Mol. Genet. 1 (9): 717–26.
doi:
10.1093/hmg/1.9.717.
PMID1284595.
Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1992). "Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY". Genomics. 11 (1): 108–14.
doi:
10.1016/0888-7543(91)90107-P.
PMID1765369.
Manz E, Schnieders F, Brechlin AM, Schmidtke J (1993). "TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome". Genomics. 17 (3): 726–31.
doi:
10.1006/geno.1993.1393.
PMID8244388.
Vogt PH, Affara N, Davey P, et al. (1998). "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997". Cytogenet. Cell Genet. 79 (1–2): 1–20.
doi:
10.1159/000134680.
PMID9533010.
Vogel T, Dittrich O, Mehraein Y, et al. (1998). "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family". Cytogenet. Cell Genet. 81 (3–4): 265–70.
doi:
10.1159/000015042.
PMID9730615.
S2CID46829106.
Ratti A, Stuppia L, Gatta V, et al. (2000). "Characterization of a new TSPY gene family member in Yq (TSPYq1)". Cytogenet. Cell Genet. 88 (1–2): 159–62.
doi:
10.1159/000015510.
PMID10773691.
S2CID20806022.
Dechend F, Williams G, Skawran B, et al. (2001). "TSPY variants in six loci on the human Y chromosome". Cytogenet. Cell Genet. 91 (1–4): 67–71.
doi:
10.1159/000056821.
PMID11173833.
S2CID21757455.
Lau Y, Chou P, Iezzoni J, et al. (2001). "Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma". Cytogenet. Cell Genet. 91 (1–4): 160–4.
doi:
10.1159/000056838.
PMID11173850.
S2CID34017469.
Testis-specific Y-encoded protein 1 is a
protein that in humans is encoded by the TSPY1gene.[3]
The protein encoded by this gene is found only in testicular tissue and may be involved in
spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional
orthologous gene is found in
mice. Two transcript variants encoding different isoforms have been found for this gene.[4] The protein is strongly overexpressed in
gonadoblastoma.[5]
Vogel T, Schmidtke J (1998). "Structure and function of TSPY, the Y-chromosome gene coding for the "testis-specific protein"". Cytogenet. Cell Genet. 80 (1–4): 209–13.
doi:
10.1159/000014982.
PMID9678360.
S2CID46875273.
Zhang JS, Yang-Feng TL, Muller U, et al. (1993). "Molecular isolation and characterization of an expressed gene from the human Y chromosome". Hum. Mol. Genet. 1 (9): 717–26.
doi:
10.1093/hmg/1.9.717.
PMID1284595.
Arnemann J, Jakubiczka S, Thüring S, Schmidtke J (1992). "Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY". Genomics. 11 (1): 108–14.
doi:
10.1016/0888-7543(91)90107-P.
PMID1765369.
Manz E, Schnieders F, Brechlin AM, Schmidtke J (1993). "TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome". Genomics. 17 (3): 726–31.
doi:
10.1006/geno.1993.1393.
PMID8244388.
Vogt PH, Affara N, Davey P, et al. (1998). "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997". Cytogenet. Cell Genet. 79 (1–2): 1–20.
doi:
10.1159/000134680.
PMID9533010.
Vogel T, Dittrich O, Mehraein Y, et al. (1998). "Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family". Cytogenet. Cell Genet. 81 (3–4): 265–70.
doi:
10.1159/000015042.
PMID9730615.
S2CID46829106.
Ratti A, Stuppia L, Gatta V, et al. (2000). "Characterization of a new TSPY gene family member in Yq (TSPYq1)". Cytogenet. Cell Genet. 88 (1–2): 159–62.
doi:
10.1159/000015510.
PMID10773691.
S2CID20806022.
Dechend F, Williams G, Skawran B, et al. (2001). "TSPY variants in six loci on the human Y chromosome". Cytogenet. Cell Genet. 91 (1–4): 67–71.
doi:
10.1159/000056821.
PMID11173833.
S2CID21757455.
Lau Y, Chou P, Iezzoni J, et al. (2001). "Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma". Cytogenet. Cell Genet. 91 (1–4): 160–4.
doi:
10.1159/000056838.
PMID11173850.
S2CID34017469.