Three prime repair exonuclease 2 is an
enzyme that in humans is encoded by the TREX2gene.[5][6]
This gene encodes a protein with
3' exonuclease activity. Enzymes with this activity are involved in
DNA replication, repair, and recombination. Similarity to an
E. coli protein suggests that this enzyme may be a subunit of
DNA polymerase III, which does not have intrinsic exonuclease activity.[6]
Esposito T, Ciccodicola A, Flagiello L, et al. (1997). "Expressed STSs and transcription of human Xq28". Gene. 187 (2): 185–91.
doi:
10.1016/S0378-1119(96)00772-X.
PMID9099879.
Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM (2003). "[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes]". Mol. Biol. (Mosk.). 36 (6): 1055–61.
PMID12500544.
Perrino FW, Krol A, Harvey S, et al. (2005). "Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins". Adv. Enzyme Regul. 44: 37–49.
doi:
10.1016/j.advenzreg.2003.11.010.
PMID15581481.
Three prime repair exonuclease 2 is an
enzyme that in humans is encoded by the TREX2gene.[5][6]
This gene encodes a protein with
3' exonuclease activity. Enzymes with this activity are involved in
DNA replication, repair, and recombination. Similarity to an
E. coli protein suggests that this enzyme may be a subunit of
DNA polymerase III, which does not have intrinsic exonuclease activity.[6]
Esposito T, Ciccodicola A, Flagiello L, et al. (1997). "Expressed STSs and transcription of human Xq28". Gene. 187 (2): 185–91.
doi:
10.1016/S0378-1119(96)00772-X.
PMID9099879.
Shevelev IV, Beliakova NV, Kravetskaia TP, Krutiakov VM (2003). "[The correcting role of autonomous 3'-->5' exonucleases in mammalian multienzyme DNA polymerase complexes]". Mol. Biol. (Mosk.). 36 (6): 1055–61.
PMID12500544.
Perrino FW, Krol A, Harvey S, et al. (2005). "Sequence variants in the 3'-->5' deoxyribonuclease TREX2: identification in a genetic screen and effects on catalysis by the recombinant proteins". Adv. Enzyme Regul. 44: 37–49.
doi:
10.1016/j.advenzreg.2003.11.010.
PMID15581481.