Tonsoku-like, DNA repair protein is a
protein that in humans is encoded by the TONSL
gene.[5]
Function
The protein encoded by this gene is thought to be a negative regulator of
NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the
cytoplasm, preventing them from entering the nucleus and interacting with the
DNA.
Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.
Tonsoku-like, DNA repair protein is a
protein that in humans is encoded by the TONSL
gene.[5]
Function
The protein encoded by this gene is thought to be a negative regulator of
NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the
cytoplasm, preventing them from entering the nucleus and interacting with the
DNA.
Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.