Certain
alleles of this gene have been statistically associated with an increased risk of developing late-onset
Alzheimer's disease.[8][9] One study has found that TOMM40 risk alleles appear twice as often in people with Alzheimer's disease than those without it.[10] Because TOMM40 is located on
chromosome 19, and is closely adjacent to APOE,[6] another gene known to be associated with Alzheimer's, another study has suggested that the statistically significant correlation of TOMM40 with Alzheimer's is due to
linkage disequilibrium.[11][12]
Walker LC, Waddell N, Ten Haaf A, et al. (2008). "Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36.
doi:
10.1007/s10549-007-9848-5.
PMID18095154.
S2CID795870.
Das B, Tao SZ, Mushnitsky R, Norin AJ (2002). "Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells". Int. J. Cancer. 94 (6): 800–6.
doi:
10.1002/ijc.1555.
PMID11745481.
S2CID20287267.
Certain
alleles of this gene have been statistically associated with an increased risk of developing late-onset
Alzheimer's disease.[8][9] One study has found that TOMM40 risk alleles appear twice as often in people with Alzheimer's disease than those without it.[10] Because TOMM40 is located on
chromosome 19, and is closely adjacent to APOE,[6] another gene known to be associated with Alzheimer's, another study has suggested that the statistically significant correlation of TOMM40 with Alzheimer's is due to
linkage disequilibrium.[11][12]
Walker LC, Waddell N, Ten Haaf A, et al. (2008). "Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36.
doi:
10.1007/s10549-007-9848-5.
PMID18095154.
S2CID795870.
Das B, Tao SZ, Mushnitsky R, Norin AJ (2002). "Genetic identity and differential expression of p38.5 (Haymaker) in human malignant and nonmalignant cells". Int. J. Cancer. 94 (6): 800–6.
doi:
10.1002/ijc.1555.
PMID11745481.
S2CID20287267.