From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transportin-3 is a
protein that in humans is encoded by the TNPO3
gene .
[5]
[6]
[7]
Function
TNPO3 is a
nuclear import receptor for serine/arginine-rich (SR) proteins, including
Serine/arginine-rich splicing factor 1 , which are essential precursor-
mRNA splicing factors .
[5]
[7]
Clinical significance
The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and
systemic sclerosis .
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000064419 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000012535 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Kataoka N, Bachorik JL, Dreyfuss G (Jul 1999).
"Transportin-SR, a nuclear import receptor for SR proteins" . J Cell Biol . 145 (6): 1145–52.
doi :
10.1083/jcb.145.6.1145 .
PMC
2133142 .
PMID
10366588 .
^ Lai MC, Lin RI, Huang SY, Tsai CW, Tarn WY (Apr 2000).
"A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins" . J Biol Chem . 275 (11): 7950–7.
doi :
10.1074/jbc.275.11.7950 .
PMID
10713112 .
^
a
b
"Entrez Gene: TNPO3 transportin 3" .
^ Radstake TR, Gorlova O, Rueda B, et al. (May 2010).
"Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus" . Nat. Genet . 42 (5): 426–9.
doi :
10.1038/ng.565 .
PMC
2861917 .
PMID
20383147 .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Lai MC, Lin RI, Tarn WY (2001).
"Transportin-SR2 mediates nuclear import of phosphorylated SR proteins" . Proc. Natl. Acad. Sci. U.S.A . 98 (18): 10154–9.
doi :
10.1073/pnas.181354098 .
PMC
56931 .
PMID
11517331 .
Allemand E, Dokudovskaya S, Bordonné R, Tazi J (2003).
"A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1" . Mol. Biol. Cell . 13 (7): 2436–47.
doi :
10.1091/mbc.E02-02-0102 .
PMC
117325 .
PMID
12134081 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Scherer SW, Cheung J, MacDonald JR, et al. (2003).
"Human chromosome 7: DNA sequence and biology" . Science . 300 (5620): 767–72.
Bibcode :
2003Sci...300..767S .
doi :
10.1126/science.1083423 .
PMC
2882961 .
PMID
12690205 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Colland F, Jacq X, Trouplin V, et al. (2004).
"Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32.
doi :
10.1101/gr.2334104 .
PMC
442148 .
PMID
15231748 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Tsang HT, Connell JW, Brown SE, et al. (2006).
"A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex" . Genomics . 88 (3): 333–46.
doi :
10.1016/j.ygeno.2006.04.003 .
PMID
16730941 .
Ewing RM, Chu P, Elisma F, et al. (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .