Transcription factor E3 is a
protein that in humans is encoded by the TFE3gene.[5][6][7]
Function
TFE3, a member of the helix-loop-helix family of
transcription factors, binds to the mu-E3 motif of the
immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by OMIM][7]
A proportion of renal carcinomas (RCC) that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2
PRCC
^Henthorn PS, Stewart CC, Kadesch T, Puck JM (Feb 1992). "The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics. 11 (2): 374–8.
doi:
10.1016/0888-7543(91)90145-5.
PMID1685140.
Weterman MA, van Groningen JJ, den Hartog A, Geurts van Kessel A (2001). "Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes". Oncogene. 20 (12): 1414–24.
doi:
10.1038/sj.onc.1204213.
PMID11313885.
S2CID2671248.
Heimann P, El Housni H, Ogur G, Weterman MA, Petty EM, Vassart G (2001). "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas". Cancer Res. 61 (10): 4130–5.
PMID11358836.
Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97.
doi:
10.1021/bi002847d.
PMID11467950.
Transcription factor E3 is a
protein that in humans is encoded by the TFE3gene.[5][6][7]
Function
TFE3, a member of the helix-loop-helix family of
transcription factors, binds to the mu-E3 motif of the
immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991).[supplied by OMIM][7]
A proportion of renal carcinomas (RCC) that occur in young patients are associated with translocations involving the TFE3 gene at chromosome Xp11.2
PRCC
^Henthorn PS, Stewart CC, Kadesch T, Puck JM (Feb 1992). "The gene encoding human TFE3, a transcription factor that binds the immunoglobulin heavy-chain enhancer, maps to Xp11.22". Genomics. 11 (2): 374–8.
doi:
10.1016/0888-7543(91)90145-5.
PMID1685140.
Weterman MA, van Groningen JJ, den Hartog A, Geurts van Kessel A (2001). "Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes". Oncogene. 20 (12): 1414–24.
doi:
10.1038/sj.onc.1204213.
PMID11313885.
S2CID2671248.
Heimann P, El Housni H, Ogur G, Weterman MA, Petty EM, Vassart G (2001). "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas". Cancer Res. 61 (10): 4130–5.
PMID11358836.
Chung MC, Kim HK, Kawamoto S (2001). "TFEC can function as a transcriptional activator of the nonmuscle myosin II heavy chain-A gene in transfected cells". Biochemistry. 40 (30): 8887–97.
doi:
10.1021/bi002847d.
PMID11467950.