Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial
enzyme that is encoded by the TFB1Mgene.[5][6][7]
TFB1M is a mitochondrial methyltransferase, which uses
S-adenosyl methionine to dimethylate two highly conserved
adenosine residues at the 3'-end of the mitochondrial
12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[6][8][9]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an
in vitro system containing recombinant mitochondrial RNA polymerase and
TFAM.[10] There are no experimental data demonstrating that this function occurs
in vivo; the paralogous
TFB2M is more specific for this role.[11]
^Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94.
doi:
10.1038/ng909.
PMID12068295.
S2CID11164308.
^Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94.
doi:
10.1038/ng909.
PMID12068295.
S2CID11164308.
Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94.
doi:
10.1038/ng909.
PMID12068295.
S2CID11164308.
Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6.
doi:
10.1007/s00335-002-2218-z.
PMID12532263.
S2CID25379746.
Bykhovskaya Y, Mengesha E, Wang D, et al. (2004). "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation". Mol. Genet. Metab. 82 (1): 27–32.
doi:
10.1016/j.ymgme.2004.01.020.
PMID15110318.
Dimethyladenosine transferase 1, mitochondrial; Transcription factor B1, mitochondrial is a mitochondrial
enzyme that is encoded by the TFB1Mgene.[5][6][7]
TFB1M is a mitochondrial methyltransferase, which uses
S-adenosyl methionine to dimethylate two highly conserved
adenosine residues at the 3'-end of the mitochondrial
12S rRNA thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome.[6][8][9]
Additionally, TFB1M has been demonstrated to stimulate transcription from promoter templates in an
in vitro system containing recombinant mitochondrial RNA polymerase and
TFAM.[10] There are no experimental data demonstrating that this function occurs
in vivo; the paralogous
TFB2M is more specific for this role.[11]
^Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94.
doi:
10.1038/ng909.
PMID12068295.
S2CID11164308.
^Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94.
doi:
10.1038/ng909.
PMID12068295.
S2CID11164308.
Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94.
doi:
10.1038/ng909.
PMID12068295.
S2CID11164308.
Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6.
doi:
10.1007/s00335-002-2218-z.
PMID12532263.
S2CID25379746.
Bykhovskaya Y, Mengesha E, Wang D, et al. (2004). "Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation". Mol. Genet. Metab. 82 (1): 27–32.
doi:
10.1016/j.ymgme.2004.01.020.
PMID15110318.