From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Serine/threonine-protein kinase TAO2 is an
enzyme that in humans is encoded by the TAOK2
gene.
[5]
[6]
[7]
TAOK2 has been shown to
interact with
MAP2K6
[8] and
MAP2K3.
[8]
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000149930 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000059981 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, et al. (December 1998).
"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–364.
doi:
10.1093/dnares/5.6.355.
PMID
10048485.
-
^ Hutchison M, Berman KS, Cobb MH (October 1998).
"Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". The Journal of Biological Chemistry. 273 (44): 28625–28632.
doi:
10.1074/jbc.273.44.28625.
PMID
9786855.
-
^
"Entrez Gene: TAOK2 TAO kinase 2".
- ^
a
b Chen Z, Cobb MH (May 2001).
"Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The Journal of Biological Chemistry. 276 (19): 16070–16075.
doi:
10.1074/jbc.M100681200.
PMID
11279118.
- Chen Z, Hutchison M, Cobb MH (October 1999).
"Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". The Journal of Biological Chemistry. 274 (40): 28803–28807.
doi:
10.1074/jbc.274.40.28803.
PMID
10497253.
- Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD (February 2000).
"PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization". The Journal of Biological Chemistry. 275 (6): 4311–4322.
doi:
10.1074/jbc.275.6.4311.
PMID
10660600.
- Nakayama M, Kikuno R, Ohara O (November 2002).
"Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–1784.
doi:
10.1101/gr.406902.
PMC
187542.
PMID
12421765.
- Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD (May 2003).
"The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability". The Journal of Biological Chemistry. 278 (20): 18085–18091.
doi:
10.1074/jbc.M213064200.
PMID
12639963.
- Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH (June 2003).
"TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors". The Journal of Biological Chemistry. 278 (25): 22278–22283.
doi:
10.1074/jbc.M301173200.
PMID
12665513.
- Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ (September 2003).
"Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–6141.
doi:
10.1038/sj.onc.1206605.
PMID
13679851.
- Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J (September 2006).
"Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways". The Journal of Biological Chemistry. 281 (39): 28802–28810.
doi:
10.1074/jbc.M603627200.
PMC
1797068.
PMID
16893890.
- Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD (March 2007).
"Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing". The Journal of Biological Chemistry. 282 (9): 6484–6493.
doi:
10.1074/jbc.M608336200.
PMID
17158878.
- Wojtala RL, Tavares IA, Morton PE, Valderrama F, Thomas NS, Morris JD (August 2011).
"Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning". The Journal of Biological Chemistry. 286 (34): 30161–30170.
doi:
10.1074/jbc.M111.228320.
PMC
3191055.
PMID
21705329.
- de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, et al. (June 2012).
"Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex". Nature Neuroscience. 15 (7): 1022–1031.
doi:
10.1038/nn.3141.
PMC
4017029.
PMID
22683681.
- Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, et al. (May 2013).
"Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease". The Journal of Biological Chemistry. 288 (21): 15418–15429.
doi:
10.1074/jbc.M112.448183.
PMC
3663559.
PMID
23585562.
- Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, et al. (November 2017).
"Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells". Molecular Cancer Therapeutics. 16 (11): 2410–2421.
doi:
10.1158/1535-7163.MCT-17-0077.
PMID
28830982.
- Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, et al. (September 2019).
"Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling". Molecular Psychiatry. 24 (9): 1329–1350.
doi:
10.1038/s41380-018-0025-5.
PMC
6756231.
PMID
29467497.
- Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, et al. (May 2018).
"A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies". Acta Neuropathologica Communications. 6 (1): 37.
doi:
10.1186/s40478-018-0539-8.
PMC
5937037.
PMID
29730992.
- Scharrenberg R, Richter M, Johanns O, Meka DP, Rücker T, Murtaza N, et al. (September 2022).
"TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model". Molecular Psychiatry. 27 (11): 4707–4721.
doi:
10.1038/s41380-022-01785-3.
PMC
9734055.
PMID
36123424.
S2CID
252382956.