Transcription initiation factor TFIID subunit 8 is a
protein that in humans is encoded by the TAF8gene.[5]
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general
transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[5]
Clinical significance
Mutations of the TAF8 gene cause a neurodegenerative disorder first described in 2022[6] and presenting as severe psychomotor retardation with almost absent development, feeding problems,
microcephaly,
growth retardation, spasticity and
epilepsy.
Transcription initiation factor TFIID subunit 8 is a
protein that in humans is encoded by the TAF8gene.[5]
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general
transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[5]
Clinical significance
Mutations of the TAF8 gene cause a neurodegenerative disorder first described in 2022[6] and presenting as severe psychomotor retardation with almost absent development, feeding problems,
microcephaly,
growth retardation, spasticity and
epilepsy.