Syndecan-2 is a
protein that in humans is encoded by the SDC2gene.[5]
Function
The protein encoded by this gene is a transmembrane (type I) heparan sulfate
proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^David G, Bai XM, Van der Schueren B, Marynen P, Cassiman JJ, Van den Berghe H (June 1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development. 119 (3): 841–54.
doi:
10.1242/dev.119.3.841.
PMID8187643.
^Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83.
doi:
10.1016/s1044-7431(02)00027-1.
PMID12676536.
S2CID2317354.
Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7.
PMID1315572.
Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor". Biochemistry. 33 (46): 13918–27.
doi:
10.1021/bi00250a047.
PMID7524669.
Bolton P, Powell J, Rutter M, Buckle V, Yates JR, Ishikawa-Brush Y, Monaco AP (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1)". Psychiatr. Genet. 5 (2): 51–5.
doi:
10.1097/00041444-199522000-00001.
PMID7551962.
S2CID45132642.
Albini A, Benelli R, Presta M, Rusnati M, Ziche M, Rubartelli A, Paglialunga G, Bussolino F, Noonan D (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97.
PMID8570206.
Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, Ardouin O, Legouis R, Levilliers J, Traincard F, Betton JM, Cabanié L, Petit C (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system". J. Cell Sci. 109 (7): 1749–57.
doi:
10.1242/jcs.109.7.1749.
PMID8832397.
Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002.
doi:
10.1152/ajpgi.1996.271.6.G993.
PMID8997243.
Syndecan-2 is a
protein that in humans is encoded by the SDC2gene.[5]
Function
The protein encoded by this gene is a transmembrane (type I) heparan sulfate
proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.[6]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^David G, Bai XM, Van der Schueren B, Marynen P, Cassiman JJ, Van den Berghe H (June 1994). "Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development". Development. 119 (3): 841–54.
doi:
10.1242/dev.119.3.841.
PMID8187643.
^Maximov A, Tang TS, Bezprozvanny I (February 2003). "Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons". Mol. Cell. Neurosci. 22 (2): 271–83.
doi:
10.1016/s1044-7431(02)00027-1.
PMID12676536.
S2CID2317354.
Labarrere CA, Pitts D, Halbrook H, Faulk WP (1992). "Natural anticoagulant pathways in normal and transplanted human hearts". J. Heart Lung Transplant. 11 (2 Pt 1): 342–7.
PMID1315572.
Brown KJ, Parish CR (1994). "Histidine-rich glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor". Biochemistry. 33 (46): 13918–27.
doi:
10.1021/bi00250a047.
PMID7524669.
Bolton P, Powell J, Rutter M, Buckle V, Yates JR, Ishikawa-Brush Y, Monaco AP (1995). "Autism, mental retardation, multiple exostoses and short stature in a female with 46,X,t(X;8)(p22.13;q22.1)". Psychiatr. Genet. 5 (2): 51–5.
doi:
10.1097/00041444-199522000-00001.
PMID7551962.
S2CID45132642.
Albini A, Benelli R, Presta M, Rusnati M, Ziche M, Rubartelli A, Paglialunga G, Bussolino F, Noonan D (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97.
PMID8570206.
Soussi-Yanicostas N, Hardelin JP, Arroyo-Jimenez MM, Ardouin O, Legouis R, Levilliers J, Traincard F, Betton JM, Cabanié L, Petit C (1997). "Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous system". J. Cell Sci. 109 (7): 1749–57.
doi:
10.1242/jcs.109.7.1749.
PMID8832397.
Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C (1997). "HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells". Am. J. Physiol. 271 (6 Pt 1): G993–1002.
doi:
10.1152/ajpgi.1996.271.6.G993.
PMID8997243.