Surfactant protein D, also known as SP-D, is a
lung surfactant protein part of the collagenous family of lectins called
collectin.[5] In humans, SP-D is encoded by the SFTPDgene[6][7] and is part of the
innate immune system.[8][9] Each SP-D subunit is composed of an N-terminal domain, a
collagenous region, a nucleating neck region, and a C-terminal lectin domain.[5][10] Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.[5][10]
^Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". American Journal of Respiratory Cell and Molecular Biology. 20 (4): 759–68.
doi:
10.1165/ajrcmb.20.4.3439.
PMID10101009.
S2CID29437779.
Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, et al. (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of Biochemistry and Biophysics. 290 (1): 116–26.
doi:
10.1016/0003-9861(91)90597-C.
PMID1898081.
Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (November 1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1086 (2): 185–90.
doi:
10.1016/0005-2760(91)90006-4.
PMID1932100.
Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (August 1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics. 17 (2): 294–8.
doi:
10.1006/geno.1993.1324.
PMID8406480.
Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (February 1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids". American Journal of Respiratory Cell and Molecular Biology. 14 (2): 121–30.
doi:
10.1165/ajrcmb.14.2.8630261.
PMID8630261.
Surfactant protein D, also known as SP-D, is a
lung surfactant protein part of the collagenous family of lectins called
collectin.[5] In humans, SP-D is encoded by the SFTPDgene[6][7] and is part of the
innate immune system.[8][9] Each SP-D subunit is composed of an N-terminal domain, a
collagenous region, a nucleating neck region, and a C-terminal lectin domain.[5][10] Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.[5][10]
^Tino MJ, Wright JR (April 1999). "Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner". American Journal of Respiratory Cell and Molecular Biology. 20 (4): 759–68.
doi:
10.1165/ajrcmb.20.4.3439.
PMID10101009.
S2CID29437779.
Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, et al. (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Archives of Biochemistry and Biophysics. 290 (1): 116–26.
doi:
10.1016/0003-9861(91)90597-C.
PMID1898081.
Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (November 1991). "Characterization of pulmonary surfactant protein D: its copurification with lipids". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1086 (2): 185–90.
doi:
10.1016/0005-2760(91)90006-4.
PMID1932100.
Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (August 1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster". Genomics. 17 (2): 294–8.
doi:
10.1006/geno.1993.1324.
PMID8406480.
Rust K, Bingle L, Mariencheck W, Persson A, Crouch EC (February 1996). "Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids". American Journal of Respiratory Cell and Molecular Biology. 14 (2): 121–30.
doi:
10.1165/ajrcmb.14.2.8630261.
PMID8630261.