Stan Fields | |
---|---|
Born | Stanley Fields |
Alma mater | University of Cambridge |
Known for | Two-hybrid screening |
Scientific career | |
Institutions | |
Thesis | Sequence analysis of influenza virus RNA (1981) |
Website |
Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions. [1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator, [2] [3] and previously served as chair of the Department of Genome Sciences. [4]
Fields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology with Greg Winter and George Brownlee. [5] [6]
Fields developed the yeast two-hybrid system in 1989, [1] which has been widely used by Fields [7] [8] [9] [10] and others to identify protein-protein interactions in various organisms and biological contexts.
Along with Matt Kaeberlein and Brian Kennedy, in later work Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins. [11] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase. [12]
Stan Fields | |
---|---|
Born | Stanley Fields |
Alma mater | University of Cambridge |
Known for | Two-hybrid screening |
Scientific career | |
Institutions | |
Thesis | Sequence analysis of influenza virus RNA (1981) |
Website |
Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein–protein interactions. [1] He is currently a professor of Genome Sciences at the University of Washington and Howard Hughes Medical Institute Investigator, [2] [3] and previously served as chair of the Department of Genome Sciences. [4]
Fields was educated at the University of Cambridge where he was awarded a Doctor of Philosophy in 1981 for research carried out in the Laboratory of Molecular Biology with Greg Winter and George Brownlee. [5] [6]
Fields developed the yeast two-hybrid system in 1989, [1] which has been widely used by Fields [7] [8] [9] [10] and others to identify protein-protein interactions in various organisms and biological contexts.
Along with Matt Kaeberlein and Brian Kennedy, in later work Fields has carried out genome-wide screens for aging genes in yeast. Kaeberlein and co-workers have questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins. [11] Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target of Rapamycin (TOR) kinase. [12]