SprX sRNA | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of SprX small RNA | |
Identifiers | |
Rfam | RF02672 |
Other data | |
Domain(s) | Bacteria |
GO | GO:0040033 |
SO | SO:0000370 |
PDB structures | PDBe |
![]() | The topic of this article may not meet Wikipedia's
general notability guideline. (September 2021) |
In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus. [1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections. [2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors. [3]
SprX sRNA | |
---|---|
![]() Predicted
secondary structure and
sequence conservation of SprX small RNA | |
Identifiers | |
Rfam | RF02672 |
Other data | |
Domain(s) | Bacteria |
GO | GO:0040033 |
SO | SO:0000370 |
PDB structures | PDBe |
![]() | The topic of this article may not meet Wikipedia's
general notability guideline. (September 2021) |
In molecular biology the small pathogenicity island RNA X (alias RsaOR) gene is a bacterial non-coding RNA. It was discovered in a large-scale analysis of Staphylococcus aureus. [1] SprX was shown to influence antibiotic resistance of the bacteria to Vancomycin and Teicoplanin glycopeptides, which are used to treat MRSA infections. [2] In this study the authors identified a SprX target, stage V sporulation protein G (Spo VG). By reducing Spo VG expression levels, SprX affects S. aureus resistance to the glycopeptide antibiotics. Further work demonstrated its involvement in the regulation of pathogenicity factors. [3]