 | This article relies largely or entirely on a
single source. (January 2024) |
| Clinical data | |
|---|---|
| Trade names | Spherox |
| Other names | Spherox 10-70 spheroids/cm2 implantation suspension |
|
Routes of administration | Intra-articular |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| DrugBank | |
| UNII | |
Spheroids of human autologous matrix-associated chondrocytes, sold under the brand name Spherox, is a medication used to repair defects to the cartilage in the knee in adults who are experiencing knee pain and problems moving the knee. [1] It is used where the affected area is no larger than 10 cm2 (1.6 sq in). [1]
The most common side effects include arthralgia and joint effusion, which can cause swelling of the joint. [1]
Spherox contains spheroids (spherical aggregates) of chondrocytes, cells found in healthy cartilage, that have been prepared from the patient's own tissues. [1]
Spherox is indicated for the repair of symptomatic articular cartilage defects of the femoral condyle and the patella of the knee (International Cartilage Repair Society [ICRS] grade III or IV) with defect sizes up to 10 cm2 (1.6 sq in) in adults. [1] [2]
To prepare the medicine, a small sample is taken by arthroscopy from the patient's cartilage in the knee. [1] The cartilage cells are then grown in the laboratory to prepare a suspension of chondrocyte spheroids. [1] During arthroscopy, the medicine is placed into the damaged area of the patient's cartilage. [1] The chondrocyte spheroids attach to the cartilage within 20 minutes. [1] People treated with Spherox should follow a specific rehabilitation program including physiotherapy. [1] This allows the chondrocyte spheroids to fill in the cartilage defect. [1]
Spherox has been shown to improve symptoms and knee function in two studies in adults between 18 and 50 years of age. [1] The main measure of effectiveness was the KOOS , which is graded on a scale of 0 to 100 (where 0 means severest symptoms and 100 means no symptoms). [1] The KOOS was self-measured by participants rating the severity of their symptoms such as pain, impact on daily living, sport and recreational activities, and quality of life. [1]
- ^ a b c d e f g h i j k l m n "Spherox EPAR". European Medicines Agency. Retrieved 29 June 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Spherox : EPAR - Product Information" (PDF). European Medicines Agency. Retrieved 29 June 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
| This article relies largely or entirely on a
single source. (January 2024) |
| Clinical data | |
|---|---|
| Trade names | Spherox |
| Other names | Spherox 10-70 spheroids/cm2 implantation suspension |
|
Routes of administration | Intra-articular |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| DrugBank | |
| UNII | |
Spheroids of human autologous matrix-associated chondrocytes, sold under the brand name Spherox, is a medication used to repair defects to the cartilage in the knee in adults who are experiencing knee pain and problems moving the knee. [1] It is used where the affected area is no larger than 10 cm2 (1.6 sq in). [1]
The most common side effects include arthralgia and joint effusion, which can cause swelling of the joint. [1]
Spherox contains spheroids (spherical aggregates) of chondrocytes, cells found in healthy cartilage, that have been prepared from the patient's own tissues. [1]
Spherox is indicated for the repair of symptomatic articular cartilage defects of the femoral condyle and the patella of the knee (International Cartilage Repair Society [ICRS] grade III or IV) with defect sizes up to 10 cm2 (1.6 sq in) in adults. [1] [2]
To prepare the medicine, a small sample is taken by arthroscopy from the patient's cartilage in the knee. [1] The cartilage cells are then grown in the laboratory to prepare a suspension of chondrocyte spheroids. [1] During arthroscopy, the medicine is placed into the damaged area of the patient's cartilage. [1] The chondrocyte spheroids attach to the cartilage within 20 minutes. [1] People treated with Spherox should follow a specific rehabilitation program including physiotherapy. [1] This allows the chondrocyte spheroids to fill in the cartilage defect. [1]
Spherox has been shown to improve symptoms and knee function in two studies in adults between 18 and 50 years of age. [1] The main measure of effectiveness was the KOOS , which is graded on a scale of 0 to 100 (where 0 means severest symptoms and 100 means no symptoms). [1] The KOOS was self-measured by participants rating the severity of their symptoms such as pain, impact on daily living, sport and recreational activities, and quality of life. [1]
- ^ a b c d e f g h i j k l m n "Spherox EPAR". European Medicines Agency. Retrieved 29 June 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ^ "Spherox : EPAR - Product Information" (PDF). European Medicines Agency. Retrieved 29 June 2020. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.