26 January 2016

• 19:33 19:33, 26 January 2016 diff hist −1,649‎ Talk:U-77891/Archive 1 ‎ ←Blanked the page
• 19:32 19:32, 26 January 2016 diff hist 0‎ User:Dvwynn/sandbox ‎ ←Blanked the page current

25 January 2016

• 17:36 17:36, 25 January 2016 diff hist +2‎ U-47700 ‎ Added see also
• 17:35 17:35, 25 January 2016 diff hist −12‎ U-47700 ‎No edit summary
• 17:35 17:35, 25 January 2016 diff hist +49‎ U-47700 ‎No edit summary
• 17:34 17:34, 25 January 2016 diff hist +51‎ U-47700 ‎ Added see also
• 17:32 17:32, 25 January 2016 diff hist 0‎ AH-7921 ‎ Changed ref to series of benzamide mu agonist,
• 13:04 13:04, 25 January 2016 diff hist +470‎ Talk:U-77891 ‎ →‎Synthesis: new section
• 11:21 11:21, 25 January 2016 diff hist −90‎ Talk:U-77891/Archive 1 ‎No edit summary
• 11:20 11:20, 25 January 2016 diff hist +694‎ Talk:U-77891/Archive 1 ‎ →‎Move: new section
• 11:20 11:20, 25 January 2016 diff hist −103‎ U-77891 ‎ remove

24 January 2016

• 12:17 12:17, 24 January 2016 diff hist −42‎ U-77891 ‎No edit summary

23 January 2016

• 18:16 18:16, 23 January 2016 diff hist +124‎ m U-77891 ‎ added reference to LogP finder. If someone has access to online ChemAxiom calculator, we can also add the pKa. The pKa at 7.4 (% uncharged) is important as if only a tiny bit is uncharged, BBB transfer will be slow.
• 18:09 18:09, 23 January 2016 diff hist 0‎ m U-77891 ‎ I think that the original series have a lot of kappa agonism, so although it's an analgesic, NO WAY would it be of any use to anyone. It's all just very useful with the x10 increases with every improvement - Undergrads could do thesis on series.
• 18:02 18:02, 23 January 2016 diff hist 0‎ m U-77891 ‎ Corrected patent number of original spiro compound research which is mainly antagonists with some being agonists at the delta receptor (from the look of them). Certainly academic interest only.
• 17:58 17:58, 23 January 2016 diff hist +53‎ m U-77891 ‎ Added patent to original work on spiro derivatives and removed '11 steps as', with the march of technology, I think it's possible in 9 or 10, but still totally impractical and pointless to criminals while SO MANY simple options exist.

22 January 2016

• 13:59 13:59, 22 January 2016 diff hist +357‎ Draft talk:U-47700 (drug) ‎ →‎MoevU-77891: new section

21 January 2016

• 18:41 18:41, 21 January 2016 diff hist +15‎ Diclazepam ‎ Lorazepam is also a metabolite

20 January 2016

• 14:41 14:41, 20 January 2016 diff hist +42‎ U-77891 ‎No edit summary
• 14:38 14:38, 20 January 2016 diff hist −42‎ U-77891 ‎No edit summary
• 14:38 14:38, 20 January 2016 diff hist +10‎ U-77891 ‎No edit summary
• 14:36 14:36, 20 January 2016 diff hist −113‎ U-77891 ‎ Just left in CAS for trans isomers as that is the form tested in animal studies. The CAS for all 4 isomers exists, but I cannot see WHEN it would ever be of use. Checked patent - 11 steps because of the need to build the spiro compound.
• 13:45 13:45, 20 January 2016 diff hist +99‎ m Papaver somniferum ‎ added patent of low-morphine strains. No use for making Heroin but used by pharmaceutical companies to make semi-synthetic opioid analgesics (didn't add patent to method but complex so not usable for illicit drugs.

19 January 2016

• 15:46 15:46, 19 January 2016 diff hist +112‎ U-77891 ‎ Can't fix CAS - HELP!!
• 15:45 15:45, 19 January 2016 diff hist −112‎ U-77891 ‎No edit summary
• 15:44 15:44, 19 January 2016 diff hist −46‎ U-77891 ‎No edit summary
• 15:43 15:43, 19 January 2016 diff hist +19‎ U-77891 ‎No edit summary
• 15:39 15:39, 19 January 2016 diff hist +84‎ U-77891 ‎No edit summary
• 15:10 15:10, 19 January 2016 diff hist 0‎ m U-77891 ‎ fixed order
• 15:07 15:07, 19 January 2016 diff hist +9‎ U-77891 ‎ try again adding both CAS
• 15:05 15:05, 19 January 2016 diff hist +1‎ U-77891 ‎No edit summary
• 15:04 15:04, 19 January 2016 diff hist −1‎ U-77891 ‎No edit summary
• 15:03 15:03, 19 January 2016 diff hist −9‎ m U-77891 ‎ fixed 2 CAS numbers (?)
• 14:57 14:57, 19 January 2016 diff hist 0‎ U-77891 ‎ Changed year of synthesis based on patent application.
• 14:53 14:53, 19 January 2016 diff hist +1‎ m U-77891 ‎ Added dash to U-47700
• 14:52 14:52, 19 January 2016 diff hist +24‎ U-77891 ‎ Noted selectivity.
• 14:48 14:48, 19 January 2016 diff hist +87‎ U-77891 ‎ Added note on complexity of synthesis as I recall it from the patent. This should mean that it's impractical for clandestine chemists and thus for informational purposes (for completests studying the series).
• 14:40 14:40, 19 January 2016 diff hist +1‎ U-77891 ‎ Fix spelling
• 13:05 13:05, 19 January 2016 diff hist −1‎ Craig Harrison (British Army soldier) ‎ 2 brothers so younger, not youngest.

18 January 2016

• 20:38 20:38, 18 January 2016 diff hist +1,029‎ Portal talk:Chemistry ‎ →‎CAS Numbers: new section

17 January 2016

• 18:01 18:01, 17 January 2016 diff hist −33‎ U-77891 ‎ Added see also
• 17:58 17:58, 17 January 2016 diff hist +33‎ U-77891 ‎No edit summary
• 17:55 17:55, 17 January 2016 diff hist +1‎ U-77891 ‎No edit summary
• 17:53 17:53, 17 January 2016 diff hist +1‎ U-77891 ‎No edit summary
• 17:53 17:53, 17 January 2016 diff hist −1‎ U-77891 ‎No edit summary
• 17:52 17:52, 17 January 2016 diff hist +1‎ U-77891 ‎No edit summary
• 17:52 17:52, 17 January 2016 diff hist +8‎ U-77891 ‎No edit summary

16 January 2016

• 16:32 16:32, 16 January 2016 diff hist −1‎ U-77891 ‎ Only allows 1 CAS - function error on page-build
• 16:31 16:31, 16 January 2016 diff hist +2‎ U-77891 ‎No edit summary
• 15:30 15:30, 16 January 2016 diff hist +1‎ U-77891 ‎No edit summary