Small Cajal body specific RNA 14 | |
---|---|
Identifiers | |
Symbol | SCARNA14 |
Alt. Symbols | snoU100 |
Rfam | RF00582 |
Other data | |
RNA type | Gene; snRNA; snoRNA; scaRNA |
Domain(s) | Eukaryota |
GO | GO:0006396 GO:0015030 GO:0005730 |
SO | SO:0000275 |
PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 14 (also known as scaRNA14 or U100) is a small nucleolar RNA found in Cajal bodies.
scaRNAs are a specific class of small nucleolar RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1] [2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs. [3]
U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 which is also included in this family. [4] U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7. [5]
Small Cajal body specific RNA 14 | |
---|---|
Identifiers | |
Symbol | SCARNA14 |
Alt. Symbols | snoU100 |
Rfam | RF00582 |
Other data | |
RNA type | Gene; snRNA; snoRNA; scaRNA |
Domain(s) | Eukaryota |
GO | GO:0006396 GO:0015030 GO:0005730 |
SO | SO:0000275 |
PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 14 (also known as scaRNA14 or U100) is a small nucleolar RNA found in Cajal bodies.
scaRNAs are a specific class of small nucleolar RNAs which localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12. [1] [2] U100 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure and the conserved H/ACA-box motifs. [3]
U100 is the human orthologue of mouse H/ACA snoRNA MBII-201 which is also included in this family. [4] U100 is predicted to guide the pseudouridylation of U2 snRNA at residue U7. [5]