In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells are most frequently associated with stomach cancer, [1] but can arise from any number of tissues including the prostate, [2] bladder, gallbladder, [3] breast, colon, [4] ovarian stroma and testis. [5]
The NCI Thesaurus identifies the following types of signet ring cell
The name of the cell comes from its appearance; signet ring cells resemble signet rings. They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell mimics the appearance of a finger hole and the nucleus mimics the appearance of the face of the ring in profile.
A significant number of signet ring cells, generally, are associated with a worse prognosis. [6] [7]
SRC carcinomas can be classified using immunohistochemistry. [8]
In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas. Signet ring cells are most frequently associated with stomach cancer, [1] but can arise from any number of tissues including the prostate, [2] bladder, gallbladder, [3] breast, colon, [4] ovarian stroma and testis. [5]
The NCI Thesaurus identifies the following types of signet ring cell
The name of the cell comes from its appearance; signet ring cells resemble signet rings. They contain a large amount of mucin, which pushes the nucleus to the cell periphery. The pool of mucin in a signet ring cell mimics the appearance of a finger hole and the nucleus mimics the appearance of the face of the ring in profile.
A significant number of signet ring cells, generally, are associated with a worse prognosis. [6] [7]
SRC carcinomas can be classified using immunohistochemistry. [8]