Septimus or Septimius may refer to:

People in Ancient Rome:

• Septimus (praenomen), a praenomen or Roman personal name
• Septimia gens, an ancient Roman family
• Lucius Septimius, one of the assassins of Pompey the Great (d. 48 BC).
• Septimius Severus, Roman general and emperor from AD 193 to 211
• L. Septimius Bassianus, better known as Caracalla, the elder son of Septimius Severus, emperor from 198 to 217
• P. Septimius Geta, the younger son of Septimius Severus, emperor from 209 to 211
• Septimius (usurper), a usurper proclaimed emperor in 271 during the reign of Aurelian
• St Septimus (d. 303), martyred with SS Felix, Januarius, Fortunatus, and Audactus
• Septimius Acindynus, consul in 340
• Lucius Septimius (Roman governor), 4th century governor of Britannia Prima
• Q. Septimius Florens Tertullianus (c. 155– c. 240 AD), better known as Tertullian, theologian
• St Septimius of Iesi (died 307), bishop and saint

People from the Palmyrene Empire:

• Septimius Odaenathus, first Palmyrene king (d. 267).
• Septimius Antiochus, last Palmyrene emperor (re. 273).
• Septimius Worod, Palmyrene viceroy (fl. 266).
• Septimius Zabdas, commander of the Palmyrene armies (d. 272).

• Septimus Aspinall (1907–1976), English rugby league footballer of the 1920s and 1930s
• Septimus Atterbury (1880–1964), English football player
• Septimus Francom (1882–1965), British long-distance runner
• Septimus J. Hanna, American Civil War veteran and a judge in the Old West
• Septimus Holmes Godson (1799–1877), British barrister
• Septimus Kaikai, Sierra Leonean politician and broadcaster
• Frederick Septimus Kelly (1881–1916), Australian rower, musician, composer
• Septimus Kinneir (1871–1928), English cricketer
• Sep Lambert, Septimus Drummond "Sep" Lambert, Irish cricketer
• Septimus Norris, (1818–1862) American mechanical engineer and steam locomotive designer
• Septimus Orion, a music recording project
• Septimus Ridsdale (1840–1884), English first-class cricketer
• Septimus Robinson (1710–1765), British Army officer
• John Septimus Roe, first Surveyor-General of Western Australia
• Septimus Rutherford (1907–1975), English footballer
• Septimus Edwin Scott, (1879–1965), English painter
• Septimus Winner, (1827-1902), 19th-century American songwriter
• Septimus Warwick (1881–1953), British architect

• Septim, a number of characters and entities in The Elder Scrolls game series
• Septimus Bean and His Amazing Machine, a children's book
• Septimus Heap, a series of books by Angie Sage, as well as the main character in the series
• Septimus Warren Smith, a character in Virginia Woolf's novel Mrs Dalloway
• Doctor Septimus Pretorius, a fictional character in the 1935 film Bride of Frankenstein
• Septimus (Stardust), a fictional character in Neil Gaiman's novel Stardust
• Septimus Hodge of Tom Stoppard's play Arcadia
• Septimus Harding, the eponymous protagonist of Anthony Trollope's The Warden
• Septimus Weasley, Ron Weasley's paternal grandfather in J.K. Rowling's Harry Potter series
• Septimus Dix, the title character of the novel Septimus, by William John Locke

• Septimus (horse)
• All pages with titles containing Septimus
• Septimania, historical region in modern-day France

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