Senotherapy is an early-stage
basic research field for development of possible therapeutic agents and strategies to specifically target
cellular senescence,[1] an altered cell state associated with ageing and age-related diseases. The name derives from intent of the proposed anti-aging drug to halt "senescence".[1] As of 2019, much of the research remains preliminary and there are no drugs approved for this purpose.
Mitochondrial depleters in the case of impaired
mitophagy[14]
Senolytics – small molecules that specifically induce cell death in senescent cells,[15][16] targeting survival pathways and
anti-apoptotic mechanisms,[17]antibodies and antibody-mediated drug delivery medications. Unlike SASP inhibitors, senolytics can be effective by intermittent rather than continuous application.[18]
Senomorphics – small molecules that suppress senescent phenotypes without cell killing[19]
Gene therapy strategies – edit the genes of the cells of an organism in order to increase their resistance to aging, senile diseases and to prolong the life of the organism[3][20]
^Wahlestedt, M., Pronk, C. J., & Bryder, D. (2015). Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation. Stem cells translational medicine, 4(2), 186-194.
^Pride H, Yu Z, Sunchu B, Mochnick J, Coles A, Zhang Y, et al. (February 2015). "Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species". Biochemical and Biophysical Research Communications. 457 (4): 669–675.
doi:
10.1016/j.bbrc.2015.01.046.
PMID25615820.
Senotherapy is an early-stage
basic research field for development of possible therapeutic agents and strategies to specifically target
cellular senescence,[1] an altered cell state associated with ageing and age-related diseases. The name derives from intent of the proposed anti-aging drug to halt "senescence".[1] As of 2019, much of the research remains preliminary and there are no drugs approved for this purpose.
Mitochondrial depleters in the case of impaired
mitophagy[14]
Senolytics – small molecules that specifically induce cell death in senescent cells,[15][16] targeting survival pathways and
anti-apoptotic mechanisms,[17]antibodies and antibody-mediated drug delivery medications. Unlike SASP inhibitors, senolytics can be effective by intermittent rather than continuous application.[18]
Senomorphics – small molecules that suppress senescent phenotypes without cell killing[19]
Gene therapy strategies – edit the genes of the cells of an organism in order to increase their resistance to aging, senile diseases and to prolong the life of the organism[3][20]
^Wahlestedt, M., Pronk, C. J., & Bryder, D. (2015). Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation. Stem cells translational medicine, 4(2), 186-194.
^Pride H, Yu Z, Sunchu B, Mochnick J, Coles A, Zhang Y, et al. (February 2015). "Long-lived species have improved proteostasis compared to phylogenetically-related shorter-lived species". Biochemical and Biophysical Research Communications. 457 (4): 669–675.
doi:
10.1016/j.bbrc.2015.01.046.
PMID25615820.