Senator Clayton may refer to:

Members of the United States Senate

• John M. Clayton (1796–1856), U.S. Senator from Delaware from 1829 to 1836, from 1845 to 1849, and from 1853 to 1856
• Joshua Clayton (1744–1798), U.S. Senator from Delaware in 1798
• Powell Clayton (1833–1914), U.S. Senator from Arkansas from 1871 to 1877
• Thomas Clayton (1777–1854), U.S. Senator from Delaware from 1824 to 1827 and from 1837 to 1847

United States state senate members

• Augustin Smith Clayton (1783–1839), Georgia State Senate
• John M. Clayton (Arkansas politician) (1840–1889), Arkansas State Senate
• William C. Clayton (1831–1915), West Virginia State Senate

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