From Wikipedia, the free encyclopedia
Type of drug
A (selective) androgen receptor degrader or downregulator (SARD) is a type of
drug which interacts with the
androgen receptor (AR) such that it causes the AR to be degraded and thus
downregulated.
[1] They are under investigation for the treatment of
prostate cancer and other
androgen-dependent conditions.
[1]
As of 2017,
dimethylcurcumin (ASC-J9), a SARD, is under development for the treatment of
acne vulgaris.
[2]
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Androgens (incl.
AASTooltip anabolic–androgenic steroid) | |
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Antiandrogens |
ARTooltip Androgen receptor
antagonists | |
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Steroidogenesis inhibitors | |
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Antigonadotropins |
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D2 receptor
antagonists (
prolactin releasers) (e.g.,
domperidone,
metoclopramide,
risperidone,
haloperidol,
chlorpromazine,
sulpiride)
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Estrogens (e.g.,
bifluranol,
diethylstilbestrol,
estradiol,
estradiol esters,
ethinylestradiol,
ethinylestradiol sulfonate,
paroxypropione)
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GnRH agonists (e.g.,
leuprorelin)
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GnRH antagonists (e.g.,
cetrorelix)
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Progestogens (incl.,
chlormadinone acetate,
cyproterone acetate,
hydroxyprogesterone caproate,
gestonorone caproate,
medroxyprogesterone acetate,
megestrol acetate)
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Others | |
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ARTooltip Androgen receptor | Agonists | |
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SARMsTooltip Selective androgen receptor modulator | |
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Antagonists | |
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GPRC6A | |
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