Santi Cosma e Damiano may refer to:

• Santi Cosma e Damiano, Alcamo, church in Alcamo, Italy
• Santi Cosma e Damiano, Brescia, church in Brescia, Italy
• Santi Cosma e Damiano, Genoa, church in Genoa, Italy
• Santi Cosma e Damiano, Isernia, church in Isernia, Italy
• Santi Cosma e Damiano, Persico, church in Persico, Italy
• Santi Cosma e Damiano, Rome, church in Rome, Italy, titular church of a cardinal deacon
• Santi Cosma e Damiano a Porta Nolana, church in Naples, Italy
• Santi Cosma e Damiano ai Banchi Nuovi, church in Naples, Italy

• Santi Cosma e Damiano, Lazio, town and comune in the province of Latina, in the Lazio region of central Italy

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