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Names | |
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Systematic IUPAC name
(3S,6S,9R,10R,11S,12S,13E,15E,18S,21S)-18-{(2E,4E,8S,9S)-10-[(2S,3R,4S,5S,6R,9S,11S)-9-Ethyl-4-hydroxy-3,5,11-trimethyl-8-oxo-1-oxa-7-azaspiro[5.5]undec-2-yl]-9-hydroxy-8-methyl-2,4-decadien-2-yl}-10, 12-dihydroxy-3-(3-hydroxybenzyl)-6-isopropyl-11-methyl-9-(3-oxobutyl)-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetrone | |
Identifiers | |
3D model (
JSmol)
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ChEMBL | |
ChemSpider | |
DrugBank | |
PubChem
CID
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CompTox Dashboard (
EPA)
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Properties | |
C60H91N5O13 | |
Molar mass | 1090.4 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Sanglifehrin A is a polyketide natural product found to potently inhibit cyclophilins and have immunosuppressive activity. [1]
Isolation and characterisation of Sanglifehrins, produced by fermentation of Streptomyces sp. A92-308110 was first published by JJ Sanglier and T Fehr in 1999. [2]
Sanglifehrins are mixed polyketide / non-ribosomal peptides, and their biosynthesis requires a modular type I polyketide synthase, with one module of non-ribosomal peptide synthetase, which incorporates phenylalanine, later converted by a hydroxylase to meta-tyrosine. [3]
![]() | |
Names | |
---|---|
Systematic IUPAC name
(3S,6S,9R,10R,11S,12S,13E,15E,18S,21S)-18-{(2E,4E,8S,9S)-10-[(2S,3R,4S,5S,6R,9S,11S)-9-Ethyl-4-hydroxy-3,5,11-trimethyl-8-oxo-1-oxa-7-azaspiro[5.5]undec-2-yl]-9-hydroxy-8-methyl-2,4-decadien-2-yl}-10, 12-dihydroxy-3-(3-hydroxybenzyl)-6-isopropyl-11-methyl-9-(3-oxobutyl)-19-oxa-1,4,7,25-tetraazabicyclo[19.3.1]pentacosa-13,15-diene-2,5,8,20-tetrone | |
Identifiers | |
3D model (
JSmol)
|
|
ChEMBL | |
ChemSpider | |
DrugBank | |
PubChem
CID
|
|
CompTox Dashboard (
EPA)
|
|
| |
| |
Properties | |
C60H91N5O13 | |
Molar mass | 1090.4 g/mol |
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
|
Sanglifehrin A is a polyketide natural product found to potently inhibit cyclophilins and have immunosuppressive activity. [1]
Isolation and characterisation of Sanglifehrins, produced by fermentation of Streptomyces sp. A92-308110 was first published by JJ Sanglier and T Fehr in 1999. [2]
Sanglifehrins are mixed polyketide / non-ribosomal peptides, and their biosynthesis requires a modular type I polyketide synthase, with one module of non-ribosomal peptide synthetase, which incorporates phenylalanine, later converted by a hydroxylase to meta-tyrosine. [3]