SUPT16H

SUPT16H
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5E5B, 4Z2M, 4Z2N
Identifiers
Aliases	SUPT16H, CDC68, FACTP140, SPT16/CDC68, SPT16, SPT16 homolog, facilitates chromatin remodeling subunit, NEDDFAC
External IDs	OMIM: 605012; MGI: 1890948; HomoloGene: 5207; GeneCards: SUPT16H; OMA: SUPT16H - orthologs
Gene location ( Human)
Chr.	Chromosome 14 (human)
End	21,384,019 bp
Gene location ( Mouse)
Chr.	Chromosome 14 (mouse)
End	52,434,873 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; gonad; ; testicle; ; Achilles tendon; ; epithelium of colon; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; body of uterus; ; smooth muscle tissue;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; genital tubercle; ; tail of embryo; ; neural layer of retina; ; primitive streak; ; renal corpuscle; ; epiblast; ; tibiofemoral joint; ; medullary collecting duct; ; pineal gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; nucleosome binding; histone binding; RNA binding;
Cellular component	nucleus; nucleoplasm; chromosome; FACT complex;
Biological process	positive regulation of DNA-templated transcription, elongation; DNA replication; nucleosome disassembly; regulation of transcription, DNA-templated; transcription by RNA polymerase II; DNA repair; transcription, DNA-templated; cellular response to DNA damage stimulus; regulation of signal transduction by p53 class mediator; transcription elongation from RNA polymerase II promoter; positive regulation of transcription elongation from RNA polymerase II promoter;
	Sources: Amigo / QuickGO
Orthologs
	11198
	114741
	ENSG00000092201
	ENSMUSG00000035726
	Q9Y5B9
	Q920B9
	NM_007192
	NM_033618
	NP_009123
	NP_291096
	Wikidata
View/Edit Human	View/Edit Mouse

FACT complex subunit SPT16 is a protein that in humans is encoded by the SUPT16H gene.^[5]^[6]^[7]

Function

Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/ H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene.^[7]

Interactions

SUPT16H has been shown to interact with BAZ1B.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000092201 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035726 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D (Mar 1998). "FACT, a factor that facilitates transcript elongation through nucleosomes". Cell. 92 (1): 105–16. doi: 10.1016/S0092-8674(00)80903-4. PMID 9489704.
^ Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H (Mar 2001). "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1". Mol Cell. 7 (2): 283–92. doi: 10.1016/S1097-2765(01)00176-9. PMID 11239457.
^ ^a ^b "Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)".
^ Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi: 10.1016/S0092-8674(03)00436-7. PMID 12837248. (Retracted, see doi: 10.1016/j.cell.2012.03.008, PMID 22464333, Retraction Watch. If this is an intentional citation to a retracted paper, please replace {{ retracted|...}} with {{ retracted|...|intentional=yes}}.)

External links

Overview of all the structural information available in the PDB for UniProt: Q9Y5B9 (FACT complex subunit SPT16) at the PDBe-KB.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000092201 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035726 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9489704-5] Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D (Mar 1998). "FACT, a factor that facilitates transcript elongation through nucleosomes". Cell. 92 (1): 105–16. doi: 10.1016/S0092-8674(00)80903-4. PMID 9489704.

[pmid11239457-6] Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H (Mar 2001). "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1". Mol Cell. 7 (2): 283–92. doi: 10.1016/S1097-2765(01)00176-9. PMID 11239457.

[entrez-7] "Entrez Gene: SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)".

[pmid12837248-8] Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (Jun 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi: 10.1016/S0092-8674(03)00436-7. PMID 12837248. (Retracted, see doi: 10.1016/j.cell.2012.03.008, PMID 22464333, Retraction Watch. If this is an intentional citation to a retracted paper, please replace {{ retracted|...}} with {{ retracted|...|intentional=yes}}.)

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Function

Interactions

References

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Function

Interactions

References

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