Translocon-associated protein subunit alpha is a
protein that in humans is encoded by the SSR1gene.[5]
The signal sequence receptor (SSR) is a glycosylated
endoplasmic reticulum (ER)
membrane receptor associated with
protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD
glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several
mRNA species as a result of complex alternative
polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.[5]
Vogel F, Hartmann E, Görlich D, Rapoport TA (1991). "Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane". Eur. J. Cell Biol. 53 (2): 197–202.
PMID1964414.
Hartmann E, Prehn S (1994). "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges". FEBS Lett. 349 (3): 324–6.
doi:
10.1016/0014-5793(94)00693-8.
PMID8050590.
S2CID42968119.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hirama T, Miller CW, Koeffler HP (1999). "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation". FEBS Lett. 455 (3): 223–7.
doi:
10.1016/S0014-5793(99)00885-6.
PMID10437777.
S2CID9426244.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6.
doi:
10.1038/nbt827.
PMID12754519.
S2CID581283.
Translocon-associated protein subunit alpha is a
protein that in humans is encoded by the SSR1gene.[5]
The signal sequence receptor (SSR) is a glycosylated
endoplasmic reticulum (ER)
membrane receptor associated with
protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD
glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several
mRNA species as a result of complex alternative
polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are exclusively non-canonical.[5]
Vogel F, Hartmann E, Görlich D, Rapoport TA (1991). "Segregation of the signal sequence receptor protein in the rough endoplasmic reticulum membrane". Eur. J. Cell Biol. 53 (2): 197–202.
PMID1964414.
Hartmann E, Prehn S (1994). "The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges". FEBS Lett. 349 (3): 324–6.
doi:
10.1016/0014-5793(94)00693-8.
PMID8050590.
S2CID42968119.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4.
doi:
10.1016/0378-1119(94)90802-8.
PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56.
doi:
10.1016/S0378-1119(97)00411-3.
PMID9373149.
Hirama T, Miller CW, Koeffler HP (1999). "Translocon-associated protein alpha transcripts are induced by granulocyte-macrophage colony-stimulating factor and exhibit complex alternative polyadenylation". FEBS Lett. 455 (3): 223–7.
doi:
10.1016/S0014-5793(99)00885-6.
PMID10437777.
S2CID9426244.
Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6.
doi:
10.1038/nbt827.
PMID12754519.
S2CID581283.