From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
For the SSH-1 protocol, see
Secure Shell#Version 1
Protein phosphatase Slingshot homolog 1 is an
enzyme that in humans is encoded by the SSH1
gene .
[5]
[6]
[7]
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000084112 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000042121 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000).
"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro" . DNA Res . 7 (1): 65–73.
doi :
10.1093/dnares/7.1.65 .
PMID
10718198 .
^ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002).
"Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin" . Cell . 108 (2): 233–46.
doi :
10.1016/S0092-8674(01)00638-9 .
PMID
11832213 .
S2CID
5576208 .
^
a
b
"Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)" .
Further reading
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Endo M, Ohashi K, Sasaki Y, et al. (2003).
"Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin" . J. Neurosci . 23 (7): 2527–37.
doi :
10.1523/JNEUROSCI.23-07-02527.2003 .
PMC
6742113 .
PMID
12684437 .
Kaji N, Ohashi K, Shuin M, et al. (2003).
"Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells" . J. Biol. Chem . 278 (35): 33450–5.
doi :
10.1074/jbc.M305802200 .
PMID
12807904 .
Ohta Y, Kousaka K, Nagata-Ohashi K, et al. (2004).
"Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin" . Genes Cells . 8 (10): 811–24.
doi :
10.1046/j.1365-2443.2003.00678.x .
PMID
14531860 .
S2CID
24247372 .
Nishita M, Wang Y, Tomizawa C, et al. (2004).
"Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion" . J. Biol. Chem . 279 (8): 7193–8.
doi :
10.1074/jbc.M312591200 .
PMID
14645219 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Dai S, Sarmiere PD, Wiggan O, et al. (2004).
"Efficient Salmonella entry requires activity cycles of host ADF and cofilin" . Cell. Microbiol . 6 (5): 459–71.
doi :
10.1111/j.1462-5822.2004.00375.x .
PMID
15056216 .
S2CID
20238982 .
Nagata-Ohashi K, Ohta Y, Goto K, et al. (2004).
"A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia" . J. Cell Biol . 165 (4): 465–71.
doi :
10.1083/jcb.200401136 .
PMC
2172350 .
PMID
15159416 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Zhang Z, Niu Z, Yuan W, et al. (2005).
"Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis" . Hum. Mutat . 24 (5): 438.
doi :
10.1002/humu.9283 .
PMID
15459975 .
S2CID
22946257 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Soosairajah J, Maiti S, Wiggan O, et al. (2005).
"Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin" . EMBO J . 24 (3): 473–86.
doi :
10.1038/sj.emboj.7600543 .
PMC
548651 .
PMID
15660133 .
Wang Y, Shibasaki F, Mizuno K (2005).
"Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin" . J. Biol. Chem . 280 (13): 12683–9.
doi :
10.1074/jbc.M411494200 .
PMID
15671020 .
Nishita M, Tomizawa C, Yamamoto M, et al. (2006).
"Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration" . J. Cell Biol . 171 (2): 349–59.
doi :
10.1083/jcb.200504029 .
PMC
2171197 .
PMID
16230460 .
Yamamoto M, Nagata-Ohashi K, Ohta Y, et al. (2006).
"Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L" . FEBS Lett . 580 (7): 1789–94.
doi :
10.1016/j.febslet.2006.02.034 .
PMID
16513117 .
S2CID
27347823 .
Cai L, Marshall TW, Uetrecht AC, et al. (2007).
"Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge" . Cell . 128 (5): 915–29.
doi :
10.1016/j.cell.2007.01.031 .
PMC
2630706 .
PMID
17350576 .
Kligys K, Claiborne JN, DeBiase PJ, et al. (2007).
"The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes" . J. Biol. Chem . 282 (44): 32520–8.
doi :
10.1074/jbc.M707041200 .
PMC
2754063 .
PMID
17848544 .