Route 580, or Highway 580, may refer to:

• Alberta Highway 580
• New Brunswick Route 580
• Ontario Highway 580

• A580 road

• I-580
  • Interstate 580 (California), a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5
  • Interstate 580 (Nevada), a spur connecting Carson City, Nevada to Reno, Nevada (also signed as U.S. Route 395)
  • Interstate 580 (Nebraska), a former route and now part of U.S. Route 75 in Omaha, Nebraska
• SR 580
• Route 580
• MD 580
• CR 580
• PA 580
• PR-580
• Spur 580

This article includes a list of roads, streets, highways, or other routes that are associated with the same title.
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