SRPRB (GENE)

SRPRB
Identifiers
Aliases	SRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta
External IDs	OMIM: 616883; MGI: 102964; HomoloGene: 6332; GeneCards: SRPRB; OMA: SRPRB - orthologs
Gene location ( Human)
Chr.	Chromosome 3 (human)
End	133,825,772 bp
Gene location ( Mouse)
Chr.	Chromosome 9 (mouse)
End	103,079,336 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; parotid gland; ; islet of Langerhans; ; cartilage tissue; ; tibia; ; epithelium of nasopharynx; ; stromal cell of endometrium; ; periodontal fiber; ; pericardium; ; corpus epididymis;
	Top expressed in
	saccule; ; otic placode; ; yolk sac; ; spermatocyte; ; renal corpuscle; ; neural layer of retina; ; otic vesicle; ; external carotid artery; ; parotid gland; ; internal carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; signal recognition particle binding; GTP binding;
Cellular component	endoplasmic reticulum membrane; cytoplasmic microtubule; cytoplasm; integral component of membrane; signal recognition particle receptor complex; intracellular anatomical structure; endoplasmic reticulum; membrane;
Biological process	IRE1-mediated unfolded protein response;
	Sources: Amigo / QuickGO
Orthologs
	58477
	20818
	ENSG00000144867
	ENSMUSG00000032553
	Q9Y5M8
	P47758
	NM_021203; NM_001379313
	NM_009275
	NP_067026; NP_001366242
	NP_033301
	Wikidata
View/Edit Human	View/Edit Mouse

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.^[5]^[6]^[7]

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144867 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032553 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi: 10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.
^ Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi: 10.1074/jbc.M003215200. PMID 10859309.
^ ^a ^b "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi: 10.1083/jcb.146.4.723. PMC 2156146. PMID 10459008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. doi: 10.3748/wjg.v9.i8.1719. PMC 4611530. PMID 12918107.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi: 10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117. PMID 16303743.
Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi: 10.1007/s11033-006-9007-9. PMID 17080297. S2CID 1871553.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: 10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144867 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032553 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7844142-5] Miller JD, Tajima S, Lauffer L, Walter P (Mar 1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane". J Cell Biol. 128 (3): 273–82. doi: 10.1083/jcb.128.3.273. PMC 2120348. PMID 7844142.

[pmid10859309-6] Legate KR, Falcone D, Andrews DW (Oct 2000). "Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit". J Biol Chem. 275 (35): 27439–46. doi: 10.1074/jbc.M003215200. PMID 10859309.

[entrez-7] "Entrez Gene: SRPRB signal recognition particle receptor, B subunit".

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