Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a
protein that in humans is encoded by the SRGNgene.[5] It is primarily expressed in hematopoietic cells and endothelial cells,[6] and is the only known intracellular proteoglycan.[7]
Function
This gene encodes a protein best known as a
hematopoietic cellgranule proteoglycan.
Proteoglycans stored in the
secretory granules of many hematopoietic cells also contain a
protease-resistant peptide core, which may be important for neutralizing
hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of
granzymes and
perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated
apoptosis.[5][8]
Mattei MG, Périn JP, Alliel PM, Bonnet F, Maillet P, Passage E, Mattei JF, Jollès P (April 1989). "Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization". Human Genetics. 82 (1): 87–8.
doi:
10.1007/BF00288281.
PMID2714783.
S2CID1378271.
Schick BP, Jacoby JA (October 1995). "Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes". Journal of Cellular Physiology. 165 (1): 96–106.
doi:
10.1002/jcp.1041650113.
PMID7559813.
S2CID1455744.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (December 1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50.
doi:
10.1016/0378-1119(94)90433-2.
PMID7821789.
Kolset SO, Mann DM, Uhlin-Hansen L, Winberg JO, Ruoslahti E (April 1996). "Serglycin-binding proteins in activated macrophages and platelets". Journal of Leukocyte Biology. 59 (4): 545–54.
doi:
10.1002/jlb.59.4.545.
PMID8613703.
S2CID23125881.
Omtvedt LA, Kolset SO, Thoen J, Førre Y, Gill MR (2001). "Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases". Scandinavian Journal of Rheumatology. 30 (3): 164–6.
doi:
10.1080/030097401300162941.
PMID11469527.
S2CID218854509.
Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a
protein that in humans is encoded by the SRGNgene.[5] It is primarily expressed in hematopoietic cells and endothelial cells,[6] and is the only known intracellular proteoglycan.[7]
Function
This gene encodes a protein best known as a
hematopoietic cellgranule proteoglycan.
Proteoglycans stored in the
secretory granules of many hematopoietic cells also contain a
protease-resistant peptide core, which may be important for neutralizing
hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of
granzymes and
perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated
apoptosis.[5][8]
Mattei MG, Périn JP, Alliel PM, Bonnet F, Maillet P, Passage E, Mattei JF, Jollès P (April 1989). "Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization". Human Genetics. 82 (1): 87–8.
doi:
10.1007/BF00288281.
PMID2714783.
S2CID1378271.
Schick BP, Jacoby JA (October 1995). "Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes". Journal of Cellular Physiology. 165 (1): 96–106.
doi:
10.1002/jcp.1041650113.
PMID7559813.
S2CID1455744.
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (December 1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50.
doi:
10.1016/0378-1119(94)90433-2.
PMID7821789.
Kolset SO, Mann DM, Uhlin-Hansen L, Winberg JO, Ruoslahti E (April 1996). "Serglycin-binding proteins in activated macrophages and platelets". Journal of Leukocyte Biology. 59 (4): 545–54.
doi:
10.1002/jlb.59.4.545.
PMID8613703.
S2CID23125881.
Omtvedt LA, Kolset SO, Thoen J, Førre Y, Gill MR (2001). "Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases". Scandinavian Journal of Rheumatology. 30 (3): 164–6.
doi:
10.1080/030097401300162941.
PMID11469527.
S2CID218854509.