Sprouty homolog 2 (Drosophila), also known as SPRY2, is a
protein which in humans is encoded by the SPRY2gene.[5]
Function
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a
carboxyl-terminalcysteine-rich
domain essential for the inhibitory activity on
receptor tyrosine kinase signaling proteins and is required for growth factor stimulated
translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to
fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.[6]
^Lee CC, Putnam AJ, Miranti CK, Gustafson M, Wang LM, Vande Woude GF, Gao CF (July 2004). "Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis". Oncogene. 23 (30): 5193–202.
doi:
10.1038/sj.onc.1207646.
PMID15122328.
S2CID56279.
^Sánchez A, Setién F, Martinez N, Oliva JL, Herranz M, Fraga MF, Alaminos M, Esteller M, Rojas JM (August 2008). "Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas". Oncogene. 27 (36): 4969–72.
doi:
10.1038/onc.2008.129.
PMID18427547.
S2CID19450976.
Hanafusa H, Torii S, Yasunaga T, Nishida E (November 2002). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology. 4 (11): 850–8.
doi:
10.1038/ncb867.
PMID12402043.
S2CID31064800.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32.
doi:
10.1038/ncb978.
PMID12717443.
S2CID33846459.
Sprouty homolog 2 (Drosophila), also known as SPRY2, is a
protein which in humans is encoded by the SPRY2gene.[5]
Function
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a
carboxyl-terminalcysteine-rich
domain essential for the inhibitory activity on
receptor tyrosine kinase signaling proteins and is required for growth factor stimulated
translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to
fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.[6]
^Lee CC, Putnam AJ, Miranti CK, Gustafson M, Wang LM, Vande Woude GF, Gao CF (July 2004). "Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis". Oncogene. 23 (30): 5193–202.
doi:
10.1038/sj.onc.1207646.
PMID15122328.
S2CID56279.
^Sánchez A, Setién F, Martinez N, Oliva JL, Herranz M, Fraga MF, Alaminos M, Esteller M, Rojas JM (August 2008). "Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas". Oncogene. 27 (36): 4969–72.
doi:
10.1038/onc.2008.129.
PMID18427547.
S2CID19450976.
Hanafusa H, Torii S, Yasunaga T, Nishida E (November 2002). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway". Nature Cell Biology. 4 (11): 850–8.
doi:
10.1038/ncb867.
PMID12402043.
S2CID31064800.
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32.
doi:
10.1038/ncb978.
PMID12717443.
S2CID33846459.