SPRED3

SPRED3
Identifiers
Aliases	SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs	OMIM: 609293; MGI: 2142186; HomoloGene: 28061; GeneCards: SPRED3; OMA: SPRED3 - orthologs
Gene location ( Human)
Chr.	Chromosome 19 (human)
End	38,399,587 bp
Gene location ( Mouse)
Chr.	Chromosome 7 (mouse)
End	28,869,836 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; lateral nuclear group of thalamus; ; vena cava; ; external globus pallidus; ; right ventricle; ; pars reticulata; ; Skeletal muscle tissue of rectus abdominis; ; body of tongue; ; pons; ; subthalamic nucleus;
	Top expressed in
	visual cortex; ; primary visual cortex; ; superior frontal gyrus; ; tail of embryo; ; spermatid; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; lumbar subsegment of spinal cord; ; ventricular zone; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding;
Cellular component	membrane;
Biological process	multicellular organism development; regulation of signal transduction; negative regulation of peptidyl-threonine phosphorylation; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of protein deacetylation;
	Sources: Amigo / QuickGO
Orthologs
	399473
	101809
	ENSG00000188766
	ENSMUSG00000037239
	Q2MJR0
	Q6P6N5
	NM_001039616; NM_001042522; NM_001394336; NM_001394337; NM_001394338
	NM_182927
	NP_001035987
	NP_891557
	Wikidata
View/Edit Human	View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.^[5]

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188766 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037239 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: sprouty-related".
^ Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi: 10.1074/jbc.M405189200. PMID 15465815.

Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. doi: 10.1016/S0006-291X(03)00259-6. PMID 12646235.
Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. doi: 10.1007/s10048-003-0164-x. PMID 14618415. S2CID 35025882.
King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. doi: 10.1016/j.jhep.2005.10.031. PMID 16478641.
Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. doi: 10.1016/j.bbrc.2006.10.150. PMID 17094949.

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