Sprouty-related,
EVH1 domain-containing protein 2 is a
protein that in humans is encoded by the SPRED2gene.[5]
Function
SPRED2 is a member of the Sprouty (see
SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see
MAPK1[5]).
Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38.
doi:
10.1007/s00418-004-0725-6.
PMID15580519.
S2CID24496085.
Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23.
doi:
10.1016/j.bbrc.2006.10.150.
PMID17094949.
2jp2: Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)
Sprouty-related,
EVH1 domain-containing protein 2 is a
protein that in humans is encoded by the SPRED2gene.[5]
Function
SPRED2 is a member of the Sprouty (see
SPRY1)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see
MAPK1[5]).
Engelhardt CM, Bundschu K, Messerschmitt M, et al. (2005). "Expression and subcellular localization of Spred proteins in mouse and human tissues". Histochem. Cell Biol. 122 (6): 527–38.
doi:
10.1007/s00418-004-0725-6.
PMID15580519.
S2CID24496085.
Lock P, I ST, Straffon AF, et al. (2007). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochem. Biophys. Res. Commun. 351 (4): 1018–23.
doi:
10.1016/j.bbrc.2006.10.150.
PMID17094949.
2jp2: Solution structure and resonance assignment of the N-terminal EVH1 domain from the human Spred2 protein (Sprouty-related protein with EVH1 domain isoform 2)