Signal peptide peptidase-like 2A, also known as SPPL2A, is a human
gene.[5]
Function
This gene is a member of the
signal peptide peptidase-like protease (SPPL) family and encodes a lysosomal/late endosomal membrane protein[6] with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving
TNFα in activated
dendritic cells.[7][8] A pseudogene of this gene also lies on chromosome 15.[5]
^Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8.
doi:
10.1038/ncb1440.
PMID16829952.
S2CID129089.
Signal peptide peptidase-like 2A, also known as SPPL2A, is a human
gene.[5]
Function
This gene is a member of the
signal peptide peptidase-like protease (SPPL) family and encodes a lysosomal/late endosomal membrane protein[6] with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving
TNFα in activated
dendritic cells.[7][8] A pseudogene of this gene also lies on chromosome 15.[5]
^Friedmann E, Hauben E, Maylandt K, et al. (2006). "SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production". Nat. Cell Biol. 8 (8): 843–8.
doi:
10.1038/ncb1440.
PMID16829952.
S2CID129089.