From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Small nuclear ribonucleoprotein Sm D3 is a
protein that in humans is encoded by the SNRPD3
gene .
[5]
[6]
[7]
Function
The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis.
[7]
Interactions
SNRPD3 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000100028 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020180 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Lehmeier T, Foulaki K, Lührmann R (January 1991).
"Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5" . Nucleic Acids Res . 18 (22): 6475–84.
doi :
10.1093/nar/18.22.6475 .
PMC
332598 .
PMID
1701240 .
^ Lehmeier T, Raker V, Hermann H, Lührmann R (January 1995).
"cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction" . Proc Natl Acad Sci U S A . 91 (25): 12317–21.
Bibcode :
1994PNAS...9112317L .
doi :
10.1073/pnas.91.25.12317 .
PMC
45428 .
PMID
7527560 .
^
a
b
"Entrez Gene: SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 18kDa" .
^ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000).
"Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry" . EMBO J . 19 (23): 6569–81.
doi :
10.1093/emboj/19.23.6569 .
PMC
305846 .
PMID
11101529 .
^
a
b Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G,
Rappsilber J , Mann M, Dreyfuss G (Dec 2001).
"The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins" . Mol. Cell. Biol . 21 (24): 8289–300.
doi :
10.1128/MCB.21.24.8289-8300.2001 .
PMC
99994 .
PMID
11713266 .
^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (Dec 1999).
"Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems" . J. Cell Biol . 147 (6): 1181–94.
doi :
10.1083/jcb.147.6.1181 .
PMC
2168095 .
PMID
10601333 .
Further reading
Liu Q, Fischer U, Wang F, Dreyfuss G (1997).
"The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins" . Cell . 90 (6): 1013–21.
doi :
10.1016/S0092-8674(00)80367-0 .
PMID
9323129 .
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res . 237 (1): 63–9.
doi :
10.1006/excr.1997.3750 .
PMID
9417867 .
Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (1999).
"Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs" . Cell . 96 (3): 375–87.
doi :
10.1016/S0092-8674(00)80550-4 .
PMID
10025403 .
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (2000).
"Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems" . J. Cell Biol . 147 (6): 1181–94.
doi :
10.1083/jcb.147.6.1181 .
PMC
2168095 .
PMID
10601333 .
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000).
"Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli" . J. Cell Biol . 148 (6): 1177–86.
doi :
10.1083/jcb.148.6.1177 .
PMC
2174312 .
PMID
10725331 .
Brahms H, Raymackers J, Union A, de Keyser F, Meheus L, Lührmann R (2000).
"The C-terminal RG dipeptide repeats of the spliceosomal Sm proteins D1 and D3 contain symmetrical dimethylarginines, which form a major B-cell epitope for anti-Sm autoantibodies" . J. Biol. Chem . 275 (22): 17122–9.
doi :
10.1074/jbc.M000300200 .
hdl :
11858/00-001M-0000-0012-F7F0-E .
PMID
10747894 .
Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2001).
"Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry" . EMBO J . 19 (23): 6569–81.
doi :
10.1093/emboj/19.23.6569 .
PMC
305846 .
PMID
11101529 .
Urlaub H, Raker VA, Kostka S, Lührmann R (2001).
"Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure" . EMBO J . 20 (1–2): 187–96.
doi :
10.1093/emboj/20.1.187 .
PMC
140196 .
PMID
11226169 .
Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (2001).
"SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets" . Mol. Cell . 7 (5): 1111–7.
doi :
10.1016/S1097-2765(01)00244-1 .
PMID
11389857 .
Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (2001).
"The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins" . Mol. Cell. Biol . 21 (24): 8289–300.
doi :
10.1128/MCB.21.24.8289-8300.2001 .
PMC
99994 .
PMID
11713266 .
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002).
"Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins" . J. Biol. Chem . 277 (7): 5631–6.
doi :
10.1074/jbc.M109448200 .
PMID
11714716 .
Meister G, Eggert C, Bühler D, Brahms H, Kambach C, Fischer U (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln". Curr. Biol . 11 (24): 1990–4.
doi :
10.1016/S0960-9822(01)00592-9 .
hdl :
11858/00-001M-0000-0012-F501-7 .
PMID
11747828 .
S2CID
14742376 .
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002).
"Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component" . J. Biol. Chem . 277 (9): 7540–5.
doi :
10.1074/jbc.M110141200 .
PMID
11748230 .
Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (2002).
"A novel WD repeat protein component of the methylosome binds Sm proteins" . J. Biol. Chem . 277 (10): 8243–7.
doi :
10.1074/jbc.M109984200 .
PMID
11756452 .
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature . 414 (6866): 929–33.
doi :
10.1038/414929a .
PMID
11780068 .
S2CID
1518837 .
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002).
"Directed proteomic analysis of the human nucleolus" . Curr. Biol . 12 (1): 1–11.
doi :
10.1016/S0960-9822(01)00650-9 .
PMID
11790298 .
Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002).
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis" . RNA . 8 (4): 426–39.
doi :
10.1017/S1355838202021088 .
PMC
1370266 .
PMID
11991638 .
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002).
"Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . J. Biol. Chem . 277 (35): 31957–62.
doi :
10.1074/jbc.M203478200 .
PMID
12065586 .