SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a
protein that in humans is
encoded by the SMARCD3gene.[5][6][7]
Function
The protein encoded by this gene is a member of the
SWI/SNF family of proteins, whose members display
helicase and
ATPase activities and which are thought to regulate
transcription of certain genes by altering the
chromatin structure around those genes. The encoded protein is part of the large
ATP-dependent chromatin remodeling complex SNF/SWI and has
sequence similarity to the yeast Swp73 protein.
Multiple alternatively spliced
transcript variants have been found for this gene.[7] Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or
differentiation during
development and
disease.[8]
Nagaraja GM, Kandpal RP (January 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications. 313 (3): 654–65.
doi:
10.1016/j.bbrc.2003.12.001.
PMID14697242.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a
protein that in humans is
encoded by the SMARCD3gene.[5][6][7]
Function
The protein encoded by this gene is a member of the
SWI/SNF family of proteins, whose members display
helicase and
ATPase activities and which are thought to regulate
transcription of certain genes by altering the
chromatin structure around those genes. The encoded protein is part of the large
ATP-dependent chromatin remodeling complex SNF/SWI and has
sequence similarity to the yeast Swp73 protein.
Multiple alternatively spliced
transcript variants have been found for this gene.[7] Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or
differentiation during
development and
disease.[8]
Nagaraja GM, Kandpal RP (January 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications. 313 (3): 654–65.
doi:
10.1016/j.bbrc.2003.12.001.
PMID14697242.