Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane
protein that in humans is encoded by the SLC50A1
gene.[5] SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.[6]
SWEET1 is a broadly-expressed
glucose transporter.[6] As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear.[7] However, the bovine SLC50A1 homologue is associated with
lactose concentration in
milk,[8] and the CiRGA homologue in the
sea squirtCiona intestinalis is essential for tissue differentiation during
embryogenesis, especially the development of the
notochord.[9]
SWEET genes are common in plant genomes, with around twenty paralogues [6] functioning as both
sucrose and
hexose transporters, and are also associated with pathogen susceptibility.[6][10]
^Hamada M, Wada S, Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation. 73 (7): 364–376.
doi:
10.1111/j.1432-0436.2005.00037.x.
PMID16219040.
Barnhill JC, Stokes AJ, Koblan-Huberson M, Shimoda LM, Muraguchi A, Adra CN, Turner H (Mar 2004). "RGA protein associates with a TRPV ion channel during biosynthesis and trafficking". Journal of Cellular Biochemistry. 91 (4): 808–20.
doi:
10.1002/jcb.10775.
PMID14991772.
S2CID44629547.
Tagoh H, Kishi H, Muraguchi A (Apr 1996). "Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors". Biochemical and Biophysical Research Communications. 221 (3): 744–9.
doi:
10.1006/bbrc.1996.0667.
PMID8630032.
Sugar transporter SWEET1, also known as RAG1-activating protein 1 and stromal cell protein (SCP), is a membrane
protein that in humans is encoded by the SLC50A1
gene.[5] SWEET1 is the sole transporter from the SLC50 (SWEET) gene family present in the genomes of most animal species, with the exception of the nematode Caenorhabditis elegans, which has seven.[6]
SWEET1 is a broadly-expressed
glucose transporter.[6] As the SWEET family has been identified relatively recently, the full range of its functions in animals is not yet clear.[7] However, the bovine SLC50A1 homologue is associated with
lactose concentration in
milk,[8] and the CiRGA homologue in the
sea squirtCiona intestinalis is essential for tissue differentiation during
embryogenesis, especially the development of the
notochord.[9]
SWEET genes are common in plant genomes, with around twenty paralogues [6] functioning as both
sucrose and
hexose transporters, and are also associated with pathogen susceptibility.[6][10]
^Hamada M, Wada S, Kobayashi K, Satoh N (2005). "Ci-Rga, a gene encoding an MtN3/saliva family transmembrane protein, is essential for tissue differentiation during embryogenesis of the ascidian Ciona intestinalis". Differentiation. 73 (7): 364–376.
doi:
10.1111/j.1432-0436.2005.00037.x.
PMID16219040.
Barnhill JC, Stokes AJ, Koblan-Huberson M, Shimoda LM, Muraguchi A, Adra CN, Turner H (Mar 2004). "RGA protein associates with a TRPV ion channel during biosynthesis and trafficking". Journal of Cellular Biochemistry. 91 (4): 808–20.
doi:
10.1002/jcb.10775.
PMID14991772.
S2CID44629547.
Tagoh H, Kishi H, Muraguchi A (Apr 1996). "Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors". Biochemical and Biophysical Research Communications. 221 (3): 744–9.
doi:
10.1006/bbrc.1996.0667.
PMID8630032.