SLC27A6 (GENE)

SLC27A6
Identifiers
Aliases	SLC27A6, ACSVL2, FACVL2, FATP6, VLCS-H1, solute carrier family 27 member 6
External IDs	OMIM: 604196; MGI: 3036230; HomoloGene: 38385; GeneCards: SLC27A6; OMA: SLC27A6 - orthologs
Gene location ( Human)
Chr.	Chromosome 5 (human)
End	129,033,642 bp
Gene location ( Mouse)
Chr.	Chromosome 18 (mouse)
End	58,745,845 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right uterine tube; ; apex of heart; ; left ventricle; ; right ventricle; ; myocardium; ; testicle; ; right adrenal cortex; ; hair follicle; ; right auricle;
	Top expressed in
	blastocyst; ; spermatocyte; ; lower respiratory tract; ; lung; ; lip; ; hair; ; placenta; ; ovary; ; zone of skin; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; very long-chain fatty acid-CoA ligase activity; catalytic activity; ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity;
Cellular component	integral component of membrane; plasma membrane; sarcolemma; membrane;
Biological process	metabolism; very long-chain fatty acid metabolic process; lipid transport; fatty acid transport; fatty acid metabolic process; lipid metabolism; long-chain fatty acid transport; long-chain fatty acid metabolic process;
	Sources: Amigo / QuickGO
Orthologs
	28965
	225579
	ENSG00000113396
	ENSMUSG00000024600
	Q9Y2P4
	E9Q9W4
	NM_001017372; NM_014031; NM_001317984
	NM_001081072
	NP_001017372; NP_001304913; NP_054750
	NP_001074541
	Wikidata
View/Edit Human	View/Edit Mouse

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.^[5]^[6]^[7]

This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113396 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024600 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A (Apr 2003). "Characterization of a heart-specific fatty acid transport protein". J Biol Chem. 278 (18): 16039–44. doi: 10.1074/jbc.M211412200. PMID 12556534.
^ Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi: 10.1006/mgme.1999.2883. PMID 10479480.
^ ^a ^b "Entrez Gene: SLC27A6 solute carrier family 27 (fatty acid transporter), member 6".

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi: 10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi: 10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode: 2002PNAS...9916899M. doi: 10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Steinberg SJ, Mihalik SJ, Kim DG, et al. (2000). "The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase". J. Biol. Chem. 275 (21): 15605–8. doi: 10.1074/jbc.C000015200. PMID 10749848.
Watkins PA, Pevsner J, Steinberg SJ (2000). "Human very long-chain acyl-CoA synthetase and two human homologs: initial characterization and relationship to fatty acid transport protein". Prostaglandins Leukot. Essent. Fatty Acids. 60 (5–6): 323–8. doi: 10.1016/S0952-3278(99)80007-6. PMID 10471116.
Hirsch D, Stahl A, Lodish HF (1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8625–9. Bibcode: 1998PNAS...95.8625H. doi: 10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113396 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024600 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12556534-5] Gimeno RE, Ortegon AM, Patel S, Punreddy S, Ge P, Sun Y, Lodish HF, Stahl A (Apr 2003). "Characterization of a heart-specific fatty acid transport protein". J Biol Chem. 278 (18): 16039–44. doi: 10.1074/jbc.M211412200. PMID 12556534.

[pmid10479480-6] Steinberg SJ, Wang SJ, McGuinness MC, Watkins PA (Oct 1999). "Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein". Mol Genet Metab. 68 (1): 32–42. doi: 10.1006/mgme.1999.2883. PMID 10479480.

[entrez-7] "Entrez Gene: SLC27A6 solute carrier family 27 (fatty acid transporter), member 6".

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